Medical Treatment Alone Versus Varicocelectomy Versus Varicocelectomy and Medical Treatment
NCT ID: NCT07016867
Last Updated: 2025-06-12
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
126 participants
INTERVENTIONAL
2024-09-01
2025-08-31
Brief Summary
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Varicocele has a negative impact on spermatogenesis, testicular volume, Standard semen parameters, and fertilization, implantation, and embryo outcomes.
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Detailed Description
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Medical management, including antioxidants, could offer a potential solution with lower risks given the increasing evidence suggesting the role of oxidative stress in varicocele-induced infertility.
Physical examination of the scrotum remains the most commonly used technique to diagnose varicoceles. Palpation of the scrotum is best performed in a relaxed patient in standing position, in a warm room and carried out by a well-trained physician.
Surgical treatment of varicocele has a significant effect on semen parameters, so it is considered the 'gold standard' treatment for subfertile males with palpable varicoceles associated with abnormal semen analysis.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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Group of l-carnitine and antioxidant
About 42 male patients suffering from teratozoospermia will take medical treatment (l-carnitine and antioxidant) once daily for 3 months
l-carnitine
to compare the efficacy of medical treatment (l-carnitine and antioxidants) versus surgical treatment (varicocelectomy) versus surgical treatment and medical treatment (varicocelectomy with adjuvant medications) on pregnancy rate on varicocele related subfertility patients with isolated teratozoospermia.
Group of varicocelectomy
About 42 male patients suffering from teratozoospermia will undergo subinguinal varicocelectomy.
l-carnitine
to compare the efficacy of medical treatment (l-carnitine and antioxidants) versus surgical treatment (varicocelectomy) versus surgical treatment and medical treatment (varicocelectomy with adjuvant medications) on pregnancy rate on varicocele related subfertility patients with isolated teratozoospermia.
Group of Mixed Treatment(varicocelectomy then l-carnitine and antioxidant)
About 42 male patients suffering from teratozoospermia will undergo subinguinal varicocelectomy then adjuvant treatment (l-carnitine and antioxidant) for 3 months.
l-carnitine
to compare the efficacy of medical treatment (l-carnitine and antioxidants) versus surgical treatment (varicocelectomy) versus surgical treatment and medical treatment (varicocelectomy with adjuvant medications) on pregnancy rate on varicocele related subfertility patients with isolated teratozoospermia.
Interventions
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l-carnitine
to compare the efficacy of medical treatment (l-carnitine and antioxidants) versus surgical treatment (varicocelectomy) versus surgical treatment and medical treatment (varicocelectomy with adjuvant medications) on pregnancy rate on varicocele related subfertility patients with isolated teratozoospermia.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Men with teratozoospermia.
Exclusion Criteria
* Significant medical diseases as: Hepatic insufficiency.
* Hypersensitivity to the drugs.
* Female factor of infertility.
20 Years
50 Years
MALE
No
Sponsors
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South Valley University
OTHER
Responsible Party
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Marwan Mohamed Ali
Resident of Urology, Faculty of Medicine
Principal Investigators
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Mohammad Sayed Abdel-Kader, Professor
Role: STUDY_CHAIR
Urology Department, Faculty of Medicine, South Valley University, Qena, Egypt
Locations
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South Valley University Hospital
Qina, South Valley, Egypt
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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Isolated Teratozoospermia
Identifier Type: -
Identifier Source: org_study_id
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