Role of the Toxic Metal Cadmium in the Mechanism Producing Infertility With a Varicocele
NCT ID: NCT00044369
Last Updated: 2006-09-04
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
400 participants
OBSERVATIONAL
2000-05-31
2005-04-30
Brief Summary
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Based on preliminary findings, we will obtain testis biopsies and semen specimens from infertile men with varicocele and prospectively examining the levels of cadmium, a toxic metal, and expression of genes required for normal sperm function. The semen and biopsies will be obtained during clinically dictated procedures. Cadmium and gene expression will be compared with response to varicocele repair (i.e., increased sperm production; pregnancy).
Detailed Description
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Conditions
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Keywords
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Study Design
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DEFINED_POPULATION
PROSPECTIVE
Interventions
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Varicocele repair
Eligibility Criteria
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Inclusion Criteria
* Non-smoker
* Actively desiring children but never having initiated a pregnancy
* Female partner having no unresolved fertility issues
21 Years
55 Years
MALE
Yes
Sponsors
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National Institute of Environmental Health Sciences (NIEHS)
NIH
Principal Investigators
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Susan H Benoff, PhD
Role: PRINCIPAL_INVESTIGATOR
North Shore University Hospital
Locations
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University of Medicine and Dentistry of NJ, Robert Wood Johnson Medical School at Camden
Camden, New Jersey, United States
North Shore University Hospital
Manhasset, New York, United States
Countries
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References
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Benoff S, Gilbert BR. Varicocele and male infertility: part I. Preface. Hum Reprod Update. 2001 Jan-Feb;7(1):47-54. doi: 10.1093/humupd/7.1.47. No abstract available.
Benoff S, Hurley IR, Barcia M, Mandel FS, Cooper GW, Hershlag A. A potential role for cadmium in the etiology of varicocele-associated infertility. Fertil Steril. 1997 Feb;67(2):336-47. doi: 10.1016/S0015-0282(97)81921-8.
Benoff S, Cooper GW, Centola GM, Jacob A, Hershlag A, Hurley IR. Metal ions and human sperm mannose receptors. Andrologia. 2000 Sep;32(4-5):317-29. doi: 10.1046/j.1439-0272.2000.00401.x.
Benoff S, Jacob A, Hurley IR. Male infertility and environmental exposure to lead and cadmium. Hum Reprod Update. 2000 Mar-Apr;6(2):107-21. doi: 10.1093/humupd/6.2.107.
Other Identifiers
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10496-CP-001
Identifier Type: -
Identifier Source: org_study_id