Assessment of Seminal Levels of Cystatin C and Endoglin in Infertile Men With Varicocele

NCT ID: NCT04856579

Last Updated: 2021-04-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-01-01

Study Completion Date

2020-12-31

Brief Summary

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Varicocele is a major contributor in male infertility. The improvement of sperm parameters after varicocelectomy supports this contribution. The pathophysiological mechanisms of varicocele-induced male infertility are still under investigation. Cystatin C (Cys C) and endoglin are secreted glycoproteins that recently linked to several cellular changes common in varicocele like apoptosis and autophagy.

Detailed Description

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Subinguinal varicocelectomy under general anesthesia and complete aseptic condition was done to infertile men with varicocele

Conditions

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Varicocele Infertility, Male

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Varicocelectomy

Subinguinal varicocelectomy under general anesthesia and complete aseptic condition

Group Type OTHER

Varicocelectomy

Intervention Type PROCEDURE

Subinguinal varicocelectomy under general anesthesia and complete aseptic condition

Interventions

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Varicocelectomy

Subinguinal varicocelectomy under general anesthesia and complete aseptic condition

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Infertile men
* Varicocele
* Poor sperm parameters

Exclusion Criteria

* Men with systemic diseases
* Infertile men due to other causes than varicocele
Minimum Eligible Age

18 Years

Maximum Eligible Age

39 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Benha University

OTHER

Sponsor Role lead

Responsible Party

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Essam Mohamed El-sayed Akl

Assistant Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Benha Faculty of Medecine

Banhā, , Egypt

Site Status

Benha Faculty of Medicine

Banhā, , Egypt

Site Status

Countries

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Egypt

Other Identifiers

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RC-5-4-2021

Identifier Type: -

Identifier Source: org_study_id

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