Post Prandial Individual Responses to Different Foods

NCT ID: NCT06989164

Last Updated: 2025-12-02

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: NA
• Total Enrollment: 100 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2025-10-01
• Study Completion Date: 2028-11-30

Brief Summary

This study aims to understand why people respond differently to the same foods, especially when it comes to changes in blood sugar after eating. A continuous glucose monitors (CGMs) will be used to observe how individuals respond to specific meals and drinks (e.g., Oral Glucose Tolerance Test, OGTT). By studying these patterns, the investigators hope to identify different types of metabolism and see if certain foods or food ingredients (like fiber, amino acids, or vinegar) can help control blood sugar better for specific groups. This research will help lay the groundwork for personalized dietary advice based on a person's unique biology.

Detailed Description

Participants in the study will be provided with a continuous glucose monitor (CGM) and pre-measured cooked rice to test with different potential mitigators: fiber, acid, amino acid (e.g., leucine), whole protein, and exercise. Each of these conditions will be tested on a different day following strict instructions. For some of these tests, participants will be asked to collect a blood microsample and a saliva sample before and after eating the test meal. A stool sample will be collected at baseline.

Conditions

PreDiabetes; Diabetes Mellitus, Type 2; Healthy

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: PREVENTION
• Blinding Strategy: NONE

Study Groups

Diet Cycles

Participants will be asked to consume pre-portioned foods on different days as the first meal of the day, use a CGM, and take saliva and micro samples of blood before and after each meal.

Group Type: EXPERIMENTAL

Post prandial testing

Intervention Type: OTHER

A variety of foods, supplements, and short prescriptive exercise will be tested to see which one helps mitigate the rise is postprandial glucose after eating carbohydrate containing foods.

Interventions

Post prandial testing

A variety of foods, supplements, and short prescriptive exercise will be tested to see which one helps mitigate the rise is postprandial glucose after eating carbohydrate containing foods.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• BMI (body mass index) >19 kg/m2 but < 45 kg/m2
• HbA1c < or equal to 7.0% while not on antihyperglycemic medications
• Be willing to provide written informed consent for all study procedures.
• Able to commute to Stanford campus for on-site visits

Exclusion Criteria

• recent (<6mos) CVD (cardiovascular disease) event
• active malignancy
• kidney/liver disease
• pregnancy/lactation
• chronic inflammatory disease
• eating disorder
• bariatric surgery
• history of acute pancreatitis
• current use of antihyperglycemic, diabetogenic, or weight loss medications
• heavy alcohol use
• physical activity >2 hours/day
• inability to come to Stanford CTRU (Clinical and Translational Research Unit) for metabolic testing

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Stanford University

OTHER

Sponsor Role: lead

Responsible Party

Yue Wu

Post doctoral

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Stanford University

Stanford, California, United States

Site Status: RECRUITING

Countries

United States

Facility Contacts

Sabrina Chun Johnston, MS, RD

Role: primary

csjohn@stanford.edu

(650) 725-0169

Other Identifiers

80689

Identifier Type: -

Identifier Source: org_study_id