Diabetes and Metabolic Postprandial Responses

NCT ID: NCT00767208

Last Updated: 2009-05-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

24 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-01-31

Study Completion Date

2008-05-31

Brief Summary

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The aim of this trial was to compare postprandial metabolic response to glucose load in healthy overweight and type 2 diabetic subjects, by using glycemia, insulinemia, lipid profile, nutrient oxidation follow-up. Stable isotopes of glucose were used to assess postprandial total,exogenous and endogenous glucose kinetics.

Detailed Description

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Conditions

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Type 2 Diabetes Overweight

Study Design

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Intervention Model

PARALLEL

Blinding Strategy

SINGLE

Participants

Study Groups

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type 2 diabetic subjects

Group Type EXPERIMENTAL

oral glucose load

Intervention Type OTHER

oral ingestion of 13C labeled glucose

overweight healthy subjects

Group Type EXPERIMENTAL

oral glucose load

Intervention Type OTHER

oral ingestion of 13C labeled glucose

Interventions

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oral glucose load

oral ingestion of 13C labeled glucose

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Overweight or obese volunteers
* Healthy for one group nd type 2 diabetic for the second group
* Age between 30 and 65 years old
* Total cholesterol \< or = 7 mmol/l and triglycerides \< or = 4 mmol/l
* For diabetic group: treated by metformin and/or sulfonylurea and/or thiazolidinedione and HbA1c \< 6%
* Stable weight over last 3 months
* Informed consent

Exclusion Criteria

* No compliant subjects
* Participation in an other trial 2 months before starting this one
* Ward of court or under guardianship (sheltered adults)
* Person deprived of freedom by judicial or administrative decision
* Type 1 diabetes and type 2 diabetes treated bu insulin or acarbose
* Existence of a previously diagnosed pathology (other than type 2 diabetes)
* Previous gastro-intestinal pathology
* Treated by corticoids, anorexigens, weight loss medicines
* Alcoholism or severe tobacco consumption
Minimum Eligible Age

30 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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LESAFFRE SA

UNKNOWN

Sponsor Role collaborator

Centre de Recherche en Nutrition Humaine Rhone-Alpe

OTHER

Sponsor Role lead

Responsible Party

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CENTRE DE RECHERCHE EN NUTRITION HUMAINE RHONE ALPES

Locations

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Centre de Recherche En Nutrition Humaine Rhone Alpes

Lyon, , France

Site Status

Countries

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France

Other Identifiers

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CRNHRA-06-002

Identifier Type: -

Identifier Source: org_study_id

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