The Effect of Breathing on Cognitive Performance and Stress

NCT ID: NCT06986135

Last Updated: 2025-05-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

66 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-08-01

Study Completion Date

2025-05-01

Brief Summary

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The purpose of this study is to determine the effectiveness of different breathing techniques on biomarkers of stress and cognitive performance following the Trier Social Stress Test.

Detailed Description

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This study examined the effect of three various breathing techniques (i.e., normal breathing, prolonged exhalation, and box breathing) on biomarkers of stress and mental performance after the Trier Social Stress Test (TSST). The TSST has been shown to result in significant increases in psychological and physiological stress markers. Therefore, the goal of this study was to examine potential interventions to mitigate the effects of this psychological stressor while maintaining increased cognitive performance. Moreover, previous literature has shown various effects of breathing interventions, therefore, the investigators wished to further validate breathing techniques as an effective tool to mitigate stress and increase cognitive performance. The data from this research provided insight to real life events, allowing for a principal understanding of how to reduce stress, focused at first responder populations.

Conditions

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Stress Acute Stress Reaction Breathing Techniques Cognitive Performance

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Subjects were randomly assigned to one of three groups, between and within subject analysis occurred.
Primary Study Purpose

OTHER

Blinding Strategy

SINGLE

Participants

Study Groups

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Box Breathing group

Group to be assigned box breathing.

Group Type EXPERIMENTAL

Box Breathing

Intervention Type OTHER

Box breathing consisted of a 4 second inhale, 4 second hold, 4 second exhale, 4 second hold; for 4 minutes.

Prolonged Exhalation Breathing assignment group

Breathing group to be assigned the prolonged exhalation intervention.

Group Type EXPERIMENTAL

Prolonged Exhalation

Intervention Type OTHER

Prolonged Exhalation consisted of a deep, 3 second inhale, followed by a slow 6 second exhale through pursed lips, once every 30 seconds for 4 minutes.

Placebo (normal breathing) group

This group is not assigned a breathing technique, and acts as a placebo.

Group Type PLACEBO_COMPARATOR

Normal Breathing

Intervention Type OTHER

This was the placebo, normal breathing group was instructed to breath as they normally would for the entirety of the 4 minute period.

Interventions

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Box Breathing

Box breathing consisted of a 4 second inhale, 4 second hold, 4 second exhale, 4 second hold; for 4 minutes.

Intervention Type OTHER

Prolonged Exhalation

Prolonged Exhalation consisted of a deep, 3 second inhale, followed by a slow 6 second exhale through pursed lips, once every 30 seconds for 4 minutes.

Intervention Type OTHER

Normal Breathing

This was the placebo, normal breathing group was instructed to breath as they normally would for the entirety of the 4 minute period.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Generally healthy
* Between the ages of 18-39,
* Student at Texas State.

Exclusion Criteria

* Any known cardiovascular or metabolic disease
* Consuming any medication for psychiatric disorders (i.e., anxiety, depression, ADHD)
* Being diagnosed with any psychiatric or physical conditions
* Any major stressors in the last 30 days (i.e., birth of a child, abortion, divorce).
Minimum Eligible Age

18 Years

Maximum Eligible Age

39 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Texas State University, San Marcos

OTHER

Sponsor Role collaborator

Texas State University

OTHER

Sponsor Role lead

Responsible Party

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Matt McAllister

Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Texas State University, Metabolic & Applied Physiology Lab

San Marcos, Texas, United States

Site Status

Countries

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United States

References

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Kotlyar M, Donahue C, Thuras P, Kushner MG, O'Gorman N, Smith EA, Adson DE. Physiological response to a speech stressor presented in a virtual reality environment. Psychophysiology. 2008 Nov;45(6):1034-7. doi: 10.1111/j.1469-8986.2008.00690.x. Epub 2008 Sep 4.

Reference Type BACKGROUND
PMID: 18778321 (View on PubMed)

Allen AP, Kennedy PJ, Dockray S, Cryan JF, Dinan TG, Clarke G. The Trier Social Stress Test: Principles and practice. Neurobiol Stress. 2016 Nov 12;6:113-126. doi: 10.1016/j.ynstr.2016.11.001. eCollection 2017 Feb.

Reference Type BACKGROUND
PMID: 28229114 (View on PubMed)

Matsumoto T, Masuda T, Hotta K, Shimizu R, Ishii A, Kutsuna T, Yamamoto K, Hara M, Takahira N, Matsunaga A. Effects of prolonged expiration breathing on cardiopulmonary responses during incremental exercise. Respir Physiol Neurobiol. 2011 Sep 15;178(2):275-82. doi: 10.1016/j.resp.2011.06.025. Epub 2011 Jul 7.

Reference Type BACKGROUND
PMID: 21763472 (View on PubMed)

Narkiewicz K, van de Borne P, Montano N, Hering D, Kara T, Somers VK. Sympathetic neural outflow and chemoreflex sensitivity are related to spontaneous breathing rate in normal men. Hypertension. 2006 Jan;47(1):51-5. doi: 10.1161/01.HYP.0000197613.47649.02. Epub 2005 Dec 12.

Reference Type BACKGROUND
PMID: 16344363 (View on PubMed)

Ntovas P, Loumprinis N, Maniatakos P, Margaritidi L, Rahiotis C. The Effects of Physical Exercise on Saliva Composition: A Comprehensive Review. Dent J (Basel). 2022 Jan 5;10(1):7. doi: 10.3390/dj10010007.

Reference Type BACKGROUND
PMID: 35049605 (View on PubMed)

Dillard CC, Martaindale H, Hunter SD, McAllister MJ. Slow Breathing Reduces Biomarkers of Stress in Response to a Virtual Reality Active Shooter Training Drill. Healthcare (Basel). 2023 Aug 21;11(16):2351. doi: 10.3390/healthcare11162351.

Reference Type BACKGROUND
PMID: 37628548 (View on PubMed)

Kim HG, Cheon EJ, Bai DS, Lee YH, Koo BH. Stress and Heart Rate Variability: A Meta-Analysis and Review of the Literature. Psychiatry Investig. 2018 Mar;15(3):235-245. doi: 10.30773/pi.2017.08.17. Epub 2018 Feb 28.

Reference Type BACKGROUND
PMID: 29486547 (View on PubMed)

Other Identifiers

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IRB #9665

Identifier Type: -

Identifier Source: org_study_id

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