Cannabidiol (CBD) and Stress Response: Psychobiological Mechanisms

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

125 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-06-01

Study Completion Date

2026-11-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The aim of this study is to determine the effects of regular cannabidiol (CBD) use on the psychobiological mechanisms of the stress response. This will be achieved by comparing acute stress responses of adults who either use or do not use CBD regularly. Correlates of CBD use, including tobacco use, will be collected.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Effects of Hemp Oil on Markers of Optimal Wellness, Stress Resilience and Recovery in Healthy Subjects

NCT04294706

Sleep Stress Mood

COMPLETED NA

Stress Reduction Training to Improve Sleep Quality, Stress Physiology & Cardiovascular Disease (CVD) Risk Markers

NCT01343810

Stress, Psychological Sleep Inflammation +1 more

COMPLETED NA

The Effect of Breathing on Cognitive Performance and Stress

NCT06986135

Stress Acute Stress Reaction Breathing Techniques +1 more

COMPLETED NA

The Effects of Lavender Aromatherapy on Reducing Stress and Anxiety During MRI Procedures.

NCT01809067

Anxiety

COMPLETED NA

Stress Management in College Students

NCT05392621

Stress

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

CBD Cannabidiol Stress Acute Stress Reaction

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NA

Intervention Model

SINGLE_GROUP

Single group assignment; all participants experience baseline rest, acute stress tasks, and recovery rest.

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Experimental group

Participants will include CBD users and non users

Group Type EXPERIMENTAL

Stress Intervention

Intervention Type OTHER

Experimental Stress: Behavioral induction of acute psychosocial and physiological stress. First, participants will be provided with a speech topic and given 4 minutes to prepare a speech that they subsequently deliver in front of evaluators and a video recorder. Then, participants will complete a mental arithmetic task in front of the evaluators for 8 minutes. Then, participants will complete a cold pressor task in which they submerge their hand in ice water for 90 seconds.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Stress Intervention

Experimental Stress: Behavioral induction of acute psychosocial and physiological stress. First, participants will be provided with a speech topic and given 4 minutes to prepare a speech that they subsequently deliver in front of evaluators and a video recorder. Then, participants will complete a mental arithmetic task in front of the evaluators for 8 minutes. Then, participants will complete a cold pressor task in which they submerge their hand in ice water for 90 seconds.

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Adults who are relatively healthy and aged 21-70 years.
* Must keep a normal sleep schedule (sleep during nighttime, awake during daytime).
* Must either (1) use CBD daily/regularly or (2) not use CBD regularly.

Exclusion Criteria

* Participated in previous acute stress studies that included a similar stress induction.
* Current, unstable: major psychiatric disorder or medical condition (e.g., uncontrolled hypertension above 160/100).
* Self-reported current pregnancy.
* Self-reported current use of illicit substances (other than cannabis).
* Non-compliance with instructions for study visit (abstinence from alcohol, caffeine, physical activity, etc.)
* Students of the principal researcher

Minimum Eligible Age

21 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes