Visuomotor Control in Parkinson Disease

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

63 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-07-19

Study Completion Date

2028-12-31

Brief Summary

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Visuomotor processing is the ability to integrate visual information into motor plans and movement correction, which is highly required in daily activities such as writing and walking. As visual impairments have been reported in people with Parkinson's disease (PD), it is likely that those impairments may affect visuomotor processing ability and subsequently impair motor performance. Furthermore, people with PD and freezing of gait (FOG) have exhibited poorer visual perception than those without FOG, yet the differences of visuomotor control have not been well investigated. Additionally, little did the studies apply neurophysiological assessment to investigate the associated neural mechanisms. This study aims to investigate behavioral and neurophysiological differences in visuomotor control among people with PD and FOG (freezers), without FOG (non-freezers), and age-matched healthy controls. Sixty-three participants, 21 freezers, 21 non-freezers, and 21 age-matched healthy controls, will be enrolled in this study. Behavioral assessments, including a manual control task and visual perception tests will be used to evaluate visuomotor and visual perceptual abilities. Neurophysiological correlates, including corticomotor excitability and corticocortical connectivity between V1-M1 and PPC-M1, will be examined using transcranial magnetic stimulation. It is hypothesized that freezers will demonstrate the greatest visuomotor impairments and disrupted corticocortical connectivity compared to non-freezers and controls. By integrating behavioral and neurophysiological outcomes, this study seeks to unravel the mechanisms linking visual and motor impairments to FOG, ultimately providing insights into targeted interventions to improve visuomotor processing and motor performance in PD.

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Detailed Description

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Conditions

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Parkinson Disease

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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FOG

Participants with Parkinson disease and freezing of gait

No interventions assigned to this group

NFOG

Participants with Parkinson disease without freezing of gait

No interventions assigned to this group

CON

Age-matched healthy adults

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* age above 18
* able to follow the researchers' instructions
* normal or correct-to-normal vision to view a computer screen

Exclusion Criteria

* neurological disorders other than PD
* diagnosed psychological disorders or a tendency of anxiety and/or depression
* a self-history of seizure or a family history of epilepsy
* deep brain stimulation or pacemaker implanted
* unstable cardiovascular diseases or other uncontrolled medical conditions
* pregnant
* surgical history, severe injury, or severe tremor of their upper extremities that can affect their movements in the past 6 months

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes