Temporal Relationship Between Motor Fluctuations and Nonmotor Fluctuations

NCT ID: NCT02060695

Last Updated: 2017-05-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

800 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-09-30

Study Completion Date

2031-06-30

Brief Summary

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The purpose of this study is to determine the temporal relationship between motor fluctuations and non-motor fluctuations in persons with Parkinson's disease.

Observational study case-only

Detailed Description

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Objectives

1. how many patients will experience motor or nonmotor fluctuation during follow-up period?
2. in how many patients, does motor fluctuation precede nonmotor fluctuation?
3. in how many patients, does nonmotor fluctuation precede motor fluctuation?

Participants: persons with Parkinson disease in early stage who does not have motor or nonmotor fluctuation

Recruitment period: 3 years from the commencement of the study Follow-up period: 3 years for each participants

Conditions

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Parkinson Disease

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* clinical diagnosis of Parkinson disease by United Kingdom Parkinson's Disease Society Brain Bank criteria
* early stage

Exclusion Criteria

* dementia (MMSE\<26)
* persons who refuse participating
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Seoul National University Hospital

OTHER

Sponsor Role lead

Responsible Party

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BS Jeon

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Beom S Jeon, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Seoul National University Hospital

Locations

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Seoul National University Hospital

Seoul, , South Korea

Site Status RECRUITING

Countries

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South Korea

Central Contacts

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Beom S Jeon, MD, PhD

Role: CONTACT

82-2-2072-2876

Facility Contacts

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Beom S Jeon, MD, PhD

Role: primary

82-2-2072-2876

References

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Witjas T, Kaphan E, Azulay JP, Blin O, Ceccaldi M, Pouget J, Poncet M, Cherif AA. Nonmotor fluctuations in Parkinson's disease: frequent and disabling. Neurology. 2002 Aug 13;59(3):408-13. doi: 10.1212/wnl.59.3.408.

Reference Type BACKGROUND
PMID: 12177375 (View on PubMed)

Resnick RJ, Kole HK, Racker E. Multiple changes induced by cholera toxin contribute to the stimulation of aerobic lactate production in rat-1 fibroblasts. Arch Biochem Biophys. 1991 May 1;286(2):579-85. doi: 10.1016/0003-9861(91)90083-u.

Reference Type BACKGROUND
PMID: 1654794 (View on PubMed)

Stacy M, Hauser R. Development of a Patient Questionnaire to facilitate recognition of motor and non-motor wearing-off in Parkinson's disease. J Neural Transm (Vienna). 2007 Feb;114(2):211-7. doi: 10.1007/s00702-006-0554-y. Epub 2006 Aug 10.

Reference Type BACKGROUND
PMID: 16897594 (View on PubMed)

Other Identifiers

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H-1109-081-378

Identifier Type: -

Identifier Source: org_study_id

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