Pathophysiology of Neuronal Oscillations Within Subthalamo-cortical Loops in Parkinson's Disease

NCT ID: NCT01284686

Last Updated: 2022-07-29

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 23 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2012-03-26
• Study Completion Date: 2015-05-27

Brief Summary

Neuronal activity in circuits between the basal ganglia (BG) and motor cortical areas is abnormally synchronised and rhythmic. The oscillatory activity prevails at 8-30 Hz in untreated Parkinson's Disease (PD) and its amplitude at both subthalamic and cortical levels inversely correlates with motor impairment. Moreover, these different levels in BG-cortical loops are coherent in this frequency band. The 8-30 Hz activity is suppressed by treatment following treatment with dopaminergic drugs and is partially suppressed prior to and during voluntary movements. An unanswered question is how do BG-cortical loops become so prominently engaged in this oscillatory activity? One possible explanation is that the resonance frequencies of the loops fall in the 8-30 Hz band in the untreated state, so that oscillations in this band are transmitted particularly well. This hypothesis was confirmed in a previous series of experiments.The aim is to determine whether the resonance frequency within BG-cortical loops is correlated to the BG-cortical coherence frequency (with 20 subjets during 24 months).

Detailed Description

Methods: Record STN-cortex LFP coherence pattern and then stimulate STN (at 0, 5, 10, 15, 20, 25, 30 Hz) in newly implanted patients at rest and during simple and complex motor tasks while recording the steady state evoked potential over the cortex using EEG. The resonance frequency will be calculated as previously (Eusebio et al, Brain 2009). Experiments will be carried out both in the OFF medication and ON medication condition.

Conditions

Parkinson's Disease; Pathophysiology of Neuronal Oscillations Within Subthalamo-cortical Loops

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: OTHER
• Blinding Strategy: NONE

Study Groups

dopamine

ON DOPA:The patient will take his usual treatment with dopamine

Group Type: ACTIVE_COMPARATOR

subthalamo-cortical loops stimulation in a one-sided and bipolar way

Intervention Type: OTHER

Record STN-cortex LFP coherence pattern and then stimulate STN (at 0, 5, 10, 15, 20, 25, 30 Hz) in newly implanted patients

without dopa

OFF Dopa: The patient will be deprived of his treatment usual dopaminergique for at least 12 hours

Group Type: EXPERIMENTAL

subthalamo-cortical loops stimulation in a one-sided and bipolar way

Intervention Type: OTHER

Record STN-cortex LFP coherence pattern and then stimulate STN (at 0, 5, 10, 15, 20, 25, 30 Hz) in newly implanted patients

Interventions

subthalamo-cortical loops stimulation in a one-sided and bipolar way

Record STN-cortex LFP coherence pattern and then stimulate STN (at 0, 5, 10, 15, 20, 25, 30 Hz) in newly implanted patients

Intervention Type: OTHER

subthalamo-cortical loops stimulation in a one-sided and bipolar way

Record STN-cortex LFP coherence pattern and then stimulate STN (at 0, 5, 10, 15, 20, 25, 30 Hz) in newly implanted patients

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Parkinson's disease idiopathique evolving for more than 5 years
• Dopa-Sensibility superior to 50 %
• Electrodes of stimulation implanted in 2 NST at Timone (Pr PERAGUT)

Exclusion Criteria

• Bad tolerance of the condition OFF Dopa and\or OFF stimulation

• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Assistance Publique Hopitaux De Marseille

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Jean-Philippe AZULAY

Role: PRINCIPAL_INVESTIGATOR

APHM

Locations

APHM

Marseille, , France

Countries

France

Other Identifiers

2009-A00913-54

Identifier Type: -

Identifier Source: org_study_id