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Non-invasive Brain Mapping of Movement Facilitation in Parkinson's Disease

NCT ID: NCT05179187

Last Updated: 2024-12-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

90 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-07-06

Study Completion Date

2026-09-30

Brief Summary

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Several strategies or contexts help patients with Parkinson's disease to move more quickly or normally, however the brain mechanisms underlying these phenomena are poorly understood. The proposed studies use complimentary brain mapping techniques to understand the brain mechanisms supporting improved movements elicited by external cues. The central hypothesis is that distinct networks are involved in movement improvement depending on characteristics of the facilitating stimulus. Participants will perform movement tasks during recording of brain activity with EEG and MRI. The identified biomarkers may provide targets for future neuromodulation therapies to improve symptoms that are refractory to current treatments, such as freezing of gait.

Detailed Description

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The studies proposed here test the overarching hypothesis that different types of cues (visual targets, rhythmic auditory stimuli and reward incentives) facilitate movement through distinct neuroanatomic circuits and electrophysiological mechanisms, by leveraging known variability in behavioral cueing benefits across patients.

Aim 1 is to demonstrate behavioral dissociations between different forms of movement facilitation within patients and relate variability in cueing benefits to integrity of dissociable neuroanatomic circuits as measured by resting state and diffusion tensor magnetic resonance imaging (MRI). Aim 2 is to characterize the electrophysiological correlates of behavioral benefits for the different cue types using electroencephalography (EEG).

Patients will perform two computer tasks involving reaching and tapping movements during video recording of movements and electrophysiological recording of brain signals. Experimental manipulations involve different computer stimuli that manipulate the presence or absence of sensory and motivational movement cues. The same experimental manipulations are delivered to all individual subjects. 60 patients with Parkinson's disease and 30 healthy controls will perform the task during recording of brain waves from the scalp (EEG) and return for a second session to record brain activity with MRI. Each of the total of 2 sessions will last about 1.5 hours. Patients may be asked to delay taking their morning Parkinson's disease medications and perform clinical rating scales and questionnaires and undergo a movement disorders neurological exam.

Conditions

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Parkinson Disease

Keywords

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movement external cueing brain mapping

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

All participants undergo the same behavioral interventions in which upper extremity movements are made in response to different sensory stimuli.
Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Parkinson disease patients

Participants diagnosed with Parkinson's disease

Group Type EXPERIMENTAL

Movement task

Intervention Type BEHAVIORAL

Computer task with experimental conditions manipulating sensory and motivation cues for movement.

Healthy adults

Healthy adult age-matched controls

Group Type ACTIVE_COMPARATOR

Movement task

Intervention Type BEHAVIORAL

Computer task with experimental conditions manipulating sensory and motivation cues for movement.

Interventions

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Movement task

Computer task with experimental conditions manipulating sensory and motivation cues for movement.

Intervention Type BEHAVIORAL

Other Intervention Names

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Computer task

Eligibility Criteria

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Inclusion Criteria

* Diagnosis of Parkinson's disease based on presence of at least 2 cardinal features (tremor, rigidity or bradykinesia) OR healthy adult with no neurologic disease
* Age \> 18 years old

Exclusion Criteria

* Dementia as indicated by score on Montreal Cognitive Assessment \< 19
* Active hallucinations or psychosis
* Contraindications to MRI (metal implant, claustrophobia)
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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National Institute of Neurological Disorders and Stroke (NINDS)

NIH

Sponsor Role collaborator

University of California, Los Angeles

OTHER

Sponsor Role lead

Responsible Party

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Kathryn A. Cross, MD, PhD

Assistant Professor in Residence

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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University of California Los Angeles

Los Angeles, California, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Katy Cross, MD, PhD

Role: CONTACT

Phone: 310-206-2828

Email: [email protected]

Ipek Talu, BA

Role: CONTACT

Phone: 310-206-2828

Email: [email protected]

Facility Contacts

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Katy Cross, MD, PhD

Role: primary

Other Identifiers

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1K23NS119568

Identifier Type: NIH

Identifier Source: secondary_id

View Link

19-002135

Identifier Type: -

Identifier Source: org_study_id