Comparison of Laparoscopic Surgery and Open Surgery for Repair of Gastric Perforation

NCT ID: NCT06870604

Last Updated: 2025-03-11

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 827 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2013-01-01
• Study Completion Date: 2024-01-01

Brief Summary

Gastric perforation (GP) is a penetrating lesion of the gastric wall that accounts for 10-15% of all peptic ulcer perforations, and most GP are spontaneous perforations caused by ulcer disease. Due to the presence of gastric acid, most patients often present to the emergency department with severe abdominal or chest pain due to chemical peritonitis within a few hours of perforation. Emergency physicians often quickly diagnose GP by using a chest x-ray or CT in an upright position and the patient's symptoms. Studies have shown that about 80-85% of patients with GP had subphrenic free gas visible on x-ray in the upright position.

Surgery is currently the mainstay of treatment for most GP, and almost all cases require urgent surgical repair.2 Over the past few years, laparoscopic surgery has become increasingly popular in clinical practice due to its advantages of less pain, less scarring, and early mobility out of bed, and has become the standard treatment for many elective and emergency procedures.

Since the laparoscopic study of PPU was first published by Mouret P in 1990, investigators have launched extensive discussions on the effects of laparoscopic surgery and open surgery in patients with perforated ulcers. However, to our knowledge, there are few separate discussions on GP, and the postoperative prognosis of laparoscopic surgery for patients with GP is less clear. Therefore, the aim of this multicenter, large-scale retrospective study was to compare the clinical outcomes of laparoscopic surgery and open surgery in patients with GP, to investigate whether laparoscopic surgery is safe and feasible for patients with GP, and to provide reliable evidence for surgical strategies in patients with GP.

Conditions

Gastric Perforation

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: RETROSPECTIVE

Study Groups

the gastric perforation group

patients diagnosed as gastric perforation

do open surgery

Intervention Type: PROCEDURE

Open surgery was performed in patients undergoing gastric perforation

do laparoscopic surgery

Intervention Type: PROCEDURE

Laparoscopic surgery was performed in patients undergoing gastric perforation

Interventions

do open surgery

Open surgery was performed in patients undergoing gastric perforation

Intervention Type: PROCEDURE

do laparoscopic surgery

Laparoscopic surgery was performed in patients undergoing gastric perforation

Intervention Type: PROCEDURE

Eligibility Criteria

Inclusion Criteria

• age ≥18 years;
• patients diagnosed with gastric perforation.

Exclusion Criteria

• patients with incomplete clinical data;
• laparoscopic surgery transfer to open surgery.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 95 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Dong Peng

OTHER

Sponsor Role: lead

Responsible Party

Dong Peng

Principal Investigator

Responsibility Role: SPONSOR_INVESTIGATOR

Other Identifiers

ZZ2025-131-01

Identifier Type: -

Identifier Source: org_study_id