Laparoscopic Versus Open Appendectomy Plus Peritoneal Lavage for Acute Complicated Appendicitis Patients With Diffuse Peritonitis

NCT ID: NCT06633744

Last Updated: 2024-10-09

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Total Enrollment: 60 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2025-01-01
• Study Completion Date: 2026-12-31

Brief Summary

This study aim to evaluate the efficacy and safety of laparoscopic versus open appendectomy in the treatment of acute complicated appendicitis with diffuse peritonitis.

Detailed Description

Appendicitis is defined as inflammation of the vermiform appendix and worldwide is the most common reason for emergency abdominal surgery. Globally, the annual incidence is 96.5 to 100 cases per 100 000 adult population. For acute uncomplicated appendicitis, antibiotic therapy has emerged as the primary treatment, often allowing patients to avoid surgery. However, the management of acute complicated appendicitis requires careful consideration of various treatment options.

Complicated appendicitis, characterized by peri-appendiceal phlegmon or abscess formation, presents additional challenges and often requires a more comprehensive treatment approach. Management strategies have evolved to incorporate both conservative and surgical treatments, tailored to the patient's condition. However, for Acute complicated appendicitis with diffuse peritonitis, surgery is the only option. Acute complicated appendicitis with diffuse peritonitis is a severe abdominal emergency that often requires prompt surgical intervention. Traditionally, open appendectomy has been the standard approach. In recent years, laparoscopic appendectomy has gained popularity due to its minimally invasive nature and potential for faster recovery. Despite this, the optimal surgical approach for complicated appendicitis with diffuse peritonitis remains debated, particularly regarding the risk of postoperative complications and recovery outcomes. The primary aim of this study is to compare the efficacy and safety of laparoscopic versus open appendectomy in such cases, focusing on postoperative complications, hospital stay, and other factors influencing surgical outcomes.

Conditions

Acute Complicated Appendicitis With Diffuse Peritonitis

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: RETROSPECTIVE

Eligibility Criteria

Inclusion Criteria

Patients aged 18 or older;

Patients with diffuse peritonitis caused by a perforated appendix confirmed intraoperatively;

Patients who underwent emergency appendectomy with peritoneal lavage;

Patients who had postoperative pathological confirmation of acute appendicitis.

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Exclusion Criteria

Patients younger than 18 years;

Patients have a history of prior malignancies;

Patients with incomplete clinical or pathological records.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Shanghai Zhongshan Hospital

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Central Contacts

HONGYONG HE, Doctor

Role: CONTACT

he.hongyong@zs-hospital.sh.cn

86-17601383022

Other Identifiers

Zhongshan-HHY-07

Identifier Type: -

Identifier Source: org_study_id