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Outcome After Laparoscopic Surgery for Peptic Ulcer Perforation

NCT ID: NCT05147870

Last Updated: 2021-12-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

150 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-01-01

Study Completion Date

2021-08-31

Brief Summary

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Despite advances in laparoscopic surgery for perforated peptic ulcer (PPU), intra-abdominal abscess (IAA) is recognized as one of the commonly reported complications with relation to the extent of infectious abdominal contamination. Herein, the investigators report their experience of laparoscopic surgery for PPU with/without peritoneal irrigation and discuss postoperative outcome. The investigators retrospectively examined the electronic medical records of the patients who underwent laparoscopic surgery for perforated peptic ulcer at a single medical center in Taiwan between January 2013 and August 2021. Retrospectively, the investigators would include those patients with clinical diagnosis of PPU who underwent emergent laparoscopic surgery. The patients with previous abdominal surgery, pathologic confirmed malignant ulcer perforation or concomitant ulcer bleeding were excluded. The investigators focused on post-operative complications and outcome after laparoscopic surgery with or without peritoneal irrigation. This information can be important in improving surgical options with respect to risk and potential benefits in this setting.

Detailed Description

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Conditions

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Intraabdominal Abscess After Procedure Leakage Pneumonia Operation Wound; Infection

Keywords

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Laparoscopic surgery Perforated peptic ulcer Peritoneal irrigation Gauze wiping and suction Intra-abdominal abscess

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Irrigation group

Peritoneal irrigation

Intervention Type PROCEDURE

For patients allocated to the irrigation group, peritoneal lavage was performed at the surgeon's discretion based on surgical findings and preference.

Suction only group

Suction only

Intervention Type PROCEDURE

In the suction only group, one surgical gauze each was placed in the splenophrenic space and Morison's pouch to soak up any remaining purulent fluid followed by turning the patient into the Trendelenburg position for inspection of the lower abdominal cavity. Any interloop adhesions were carefully divided and the gauze-wiping maneuver was used to soak up the residual peritoneal fluid, and all bowel loops were investigated to the root of the mesentery.

Interventions

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Peritoneal irrigation

For patients allocated to the irrigation group, peritoneal lavage was performed at the surgeon's discretion based on surgical findings and preference.

Intervention Type PROCEDURE

Suction only

In the suction only group, one surgical gauze each was placed in the splenophrenic space and Morison's pouch to soak up any remaining purulent fluid followed by turning the patient into the Trendelenburg position for inspection of the lower abdominal cavity. Any interloop adhesions were carefully divided and the gauze-wiping maneuver was used to soak up the residual peritoneal fluid, and all bowel loops were investigated to the root of the mesentery.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* The patients with clinical diagnosis of PPU underwent laparoscopic repair surgery.

Exclusion Criteria

* The patients received surgery in an open approach or underwent laparoscopy initially but then intraoperatively converted to laparotomy.
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Chang Wei-Jung

OTHER

Sponsor Role lead

Responsible Party

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Chang Wei-Jung

Sponsor-Investigator

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Lien-Cheng Tsao, M.D.

Role: PRINCIPAL_INVESTIGATOR

Changhua Christian Hospital, Changhua, 500, Taiwan

Other Identifiers

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201021

Identifier Type: -

Identifier Source: org_study_id