Hydrogen-rich Water and Appetite in Obesity

NCT ID: NCT06722326

Last Updated: 2025-01-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

36 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-05-15

Study Completion Date

2024-12-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The main goal of this study is to investigate how dihydrogen supplementation impacts body composition, appetite, quality of life specific to obesity, and levels of the hormone GLP-1 in men and women with obesity. This randomized controlled trial aims to explore whether dihydrogen can improve these health indicators.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

The primary aim of this randomized controlled trial is to evaluate the effects of dihydrogen supplementation on body composition indices, appetite, obesity-specific quality of life, and circulating GLP-1 levels in obese men and women

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Obesity

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

DOUBLE

Participants Caregivers

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Hydrogen-rich water

One liter per day of hydrogen rich water

Group Type EXPERIMENTAL

Dietary Supplement: Hydrogen-rich water

Intervention Type DIETARY_SUPPLEMENT

Hydrogen-rich water with 12 mg of hydrogen per serving

Control water

One liter per day of tap water

Group Type PLACEBO_COMPARATOR

Dietary Supplement: Control water

Intervention Type DIETARY_SUPPLEMENT

Control water with 0 mg of hydrogen per serving

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Dietary Supplement: Hydrogen-rich water

Hydrogen-rich water with 12 mg of hydrogen per serving

Intervention Type DIETARY_SUPPLEMENT

Dietary Supplement: Control water

Control water with 0 mg of hydrogen per serving

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Age 18-65 years
* Body fat \> 30% in women and \> 25% in men
* Not physically active
* Informed consent signed

Exclusion Criteria

* Major chronic disease and acute injuries
* History of dietary supplement use during the past 4 weeks
* History of obesity pharmaceuticals use during the past 8 weeks
* No consent to randomization
* Participation in other studies
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

University of Novi Sad, Faculty of Sport and Physical Education

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Sergej Ostojic

Professor and Head of the Lab

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Applied Bioenergetics Lab

Novi Sad, Vojvodina, Serbia

Site Status

Countries

Review the countries where the study has at least one active or historical site.

Serbia

References

Explore related publications, articles, or registry entries linked to this study.

Korovljev D, Ostojic J, Todorovic N, Ostojic SM. Molecular hydrogen modulates brain glutamate/GABA-glutamine cycle in overweight humans. Arch Med Sci. 2023 Jul 13;19(4):1151-1153. doi: 10.5114/aoms/162938. eCollection 2023.

Reference Type BACKGROUND
PMID: 37560746 (View on PubMed)

Todorovic N, Baltic S, Nedeljkovic D, Kuzmanovic J, Korovljev D, Javorac D, Bijelic K, Kladar N, Tarnava A, Ostojic SM. The Effects of 8-Week Hydrogen-Rich Water Consumption on Appetite, Body Composition, Sleep Quality, and Circulating Glucagon-like Peptide-1 in Obese Men and Women (HYDRAPPET): A Randomized Controlled Trial. Medicina (Kaunas). 2025 Jul 18;61(7):1299. doi: 10.3390/medicina61071299.

Reference Type DERIVED
PMID: 40731927 (View on PubMed)

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

03-HRW-24

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Exogenous Ketones and Appetite
NCT06327464 RECRUITING NA
Attentive Eating for Weight Loss
NCT03602001 COMPLETED NA
Eating Behaviors in Shift Workers
NCT04468672 ACTIVE_NOT_RECRUITING NA
Glycogen and Appetite
NCT05417659 COMPLETED NA