Water Intake and Weight Control in Older Adults

NCT ID: NCT05843318

Last Updated: 2025-11-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

375 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-11-13

Study Completion Date

2028-03-31

Brief Summary

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This study is a randomized controlled intervention trial in adults aged 50+ years with overweight or obesity, which will compare three groups with different diet prescriptions: 1) pre-meal water consumption (500 ml, before each main meal) with a hypocaloric diet; 2) 1500 ml water consumed throughout the day with a hypocaloric diet; 3) hypocaloric diet with no instructions regarding water consumption. Smart water bottles will objectively assess water intake timing and volume. Urine osmolality, urine volume, and serum osmolality will be used as objective indicators of compliance with the water intake prescription. We will investigate changes in perceived hunger and fullness and appetite-regulating hormones as potential mechanisms by which premeal water could improve appetite regulation. We will also investigate the impact of water consumption and hydration on executive function capabilities, which may influence intervention adherence. Although increasing water intake could be an effective weight management strategy, no evidence-based recommendations exist for the timing of water intake needed for this benefit.

Detailed Description

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Conditions

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Overweight and Obesity

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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Pre-meal water + Hypocaloric diet

premeal water ( 500 ml) before each main meal, three times per day + hypocaloric diet

Group Type EXPERIMENTAL

Water intake and weight control in older adults - Premeal Water + hypocaloric diet

Intervention Type BEHAVIORAL

Individuals will be randomly assigned to one of three groups. All individuals will receive counseling in a structured hypocaloric meal plan (1200-1500 kcal) that is consistent with a healthy dietary pattern as described by the Dietary Guidelines for Americans. This group will receive specific instructions for daily water intake timing and volume.

Daily water + Hypocaloric diet

total daily water prescription (1500 ml/d) + hypocaloric diet

Group Type EXPERIMENTAL

Water intake and weight control in older adults - Total Daily Water + hypocaloric diet

Intervention Type BEHAVIORAL

Individuals will be randomly assigned to one of three groups. All individuals will receive counseling in a structured hypocaloric meal plan (1200-1500 kcal) that is consistent with a healthy dietary pattern as described by the Dietary Guidelines for Americans. This group will receive specific instructions for total daily water intake.

Hypocaloric Diet alone

hypocaloric diet with not instructions regarding water intake

Group Type ACTIVE_COMPARATOR

Water Intake and weight control in older adults - hypocaloric diet alone

Intervention Type BEHAVIORAL

Individuals will be randomly assigned to one of three groups. All individuals will receive counseling in a structured hypocaloric meal plan (1200-1500 kcal) that is consistent with a healthy dietary pattern as described by the Dietary Guidelines for Americans. This group will receive instructions in the hypocaloric diet, without specific fluid intake recommendations.

Interventions

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Water intake and weight control in older adults - Premeal Water + hypocaloric diet

Individuals will be randomly assigned to one of three groups. All individuals will receive counseling in a structured hypocaloric meal plan (1200-1500 kcal) that is consistent with a healthy dietary pattern as described by the Dietary Guidelines for Americans. This group will receive specific instructions for daily water intake timing and volume.

Intervention Type BEHAVIORAL

Water intake and weight control in older adults - Total Daily Water + hypocaloric diet

Individuals will be randomly assigned to one of three groups. All individuals will receive counseling in a structured hypocaloric meal plan (1200-1500 kcal) that is consistent with a healthy dietary pattern as described by the Dietary Guidelines for Americans. This group will receive specific instructions for total daily water intake.

Intervention Type BEHAVIORAL

Water Intake and weight control in older adults - hypocaloric diet alone

Individuals will be randomly assigned to one of three groups. All individuals will receive counseling in a structured hypocaloric meal plan (1200-1500 kcal) that is consistent with a healthy dietary pattern as described by the Dietary Guidelines for Americans. This group will receive instructions in the hypocaloric diet, without specific fluid intake recommendations.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* aged 50+ years
* BMI ≥25 kg/m2
* weight stable (+/- 2 kg) in past 6 months
* willing to provide consent and comply with study protocol

Exclusion Criteria

* usual plain drinking water intake \>1500 ml/d
* uncontrolled hypertension (\>159/99 mmHg)
* medical condition requiring specialized diet prescription (eg, T2D, CHF wih fluid restriction)
* medical condition that precludes participating in a physical activity program (eg, orthopedic injury)
* current or history of GI disease (eg, Crohn's), GI surgery, or medications which impact GI function
* allergies or aversions to foods included in the test meals
Minimum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Virginia Polytechnic Institute and State University

OTHER

Sponsor Role lead

Responsible Party

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Brenda Davy

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Brenda Davy, PhD RDN

Role: PRINCIPAL_INVESTIGATOR

Virginia Polytechnic Institute and State University

Locations

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Virginia Tech

Blacksburg, Virginia, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Brenda Davy, PhD RDN

Role: CONTACT

Phone: 540-231-6784

Email: [email protected]

Elaina Marinik, PhD

Role: CONTACT

Phone: 540-231-0923

Email: [email protected]

Facility Contacts

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Brenda M Davy, PhD

Role: primary

Elaina L Marinik, PhD

Role: backup

Other Identifiers

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22-624

Identifier Type: -

Identifier Source: org_study_id