Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
40 participants
INTERVENTIONAL
2025-02-25
2026-01-25
Brief Summary
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The hypothesis is that dexterous hand function will improve after a standard HD-tDCS dose and increase even more after personalized dose-controlled multifocal network-targeted HD-tDCS.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
BASIC_SCIENCE
SINGLE
Study Groups
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HD-tDCS with standard intervention
Participants will have three daily sessions.
Standard HD-tDCS intervention
Participants will have three sessions along with behavioral assessments.
Functional Magnetic Resonance Imaging (fMRI)
Participants will have an MRI before or after having HD-tDCS intervention.
Personalized dose-controlled multifocal network-targeted HD-tDCS.
Participants will have three daily sessions.
Multifocal network targeted HD-tDCS intervention
Participants will have three sessions along with behavioral assessments.
Functional Magnetic Resonance Imaging (fMRI)
Participants will have an MRI before or after having HD-tDCS intervention.
Interventions
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Standard HD-tDCS intervention
Participants will have three sessions along with behavioral assessments.
Multifocal network targeted HD-tDCS intervention
Participants will have three sessions along with behavioral assessments.
Functional Magnetic Resonance Imaging (fMRI)
Participants will have an MRI before or after having HD-tDCS intervention.
Eligibility Criteria
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Inclusion Criteria
* Right handed
* No history of neurological disorder
* English speaker
* Able to provide written consent prior to admission
Exclusion Criteria
* Participants are pregnant, suspect pregnancy or are attempting to become pregnant
* Have a pacemaker, intracardiac lines or any other medically implanted device or medicine pump
* Have cochlear hearing implants
* Taking drugs known to influence neural receptors that facilitate neuroplasticity (see protocol)
* Have non removable body piercings or have foreign objects in body
* Have metal anywhere in the head that could increase risk of serious injury (not including braces, dental fillings, etc.) (see protocol)
* Have a personal or family history of seizure/epilepsy
* Taking prescription drugs that lower the threshold for seizures
* Recent history of excessive alcohol consumption
* History of alcohol addiction/dependence
* Recent history of recreational drug use
* History of drug addiction/dependence
* Recent history of recreational drug use
* History of drug addiction/dependence
* Diagnosed with a stroke, brain hemorrhage, brain tumor, encephalitis.
* Diagnosed with multiple sclerosis
* Diagnosed with Parkinson's disease or Alzheimer's disease
* Diagnosed with depression in the past 6 months
* Diagnosed with attention deficit disorder, schizophrenia, manic depressive (bipolar) disorder
* Diagnosed with normal pressure hydrocephalus or increased intra-cranial pressure
* Diabetes requiring insulin treatment
* Any serious heart disorder or liver disease
65 Years
85 Years
ALL
Yes
Sponsors
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Medical University of South Carolina
OTHER
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
University of Michigan
OTHER
Responsible Party
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Michael Vesia, PhD
Assistant Professor of Kinesiology
Principal Investigators
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Michael Vesia, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Michigan
Locations
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University of Michigan
Ann Arbor, Michigan, United States
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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HUM00250171
Identifier Type: -
Identifier Source: org_study_id
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