fMRI Analysis of Aging and Awareness in Conditioning

NCT ID: NCT03655769

Last Updated: 2025-12-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

NA

Total Enrollment

16 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-11-09

Study Completion Date

2026-12-31

Brief Summary

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Cathodal Transcranial direct current stimulation (tDCS) was administered to the right parietal region in order to determine if this stimulation could disrupt awareness of the conditioned stimulus (CS) - unconditioned stimulus (US) relationship in a classical conditioning experiment.

Detailed Description

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Conditions

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Transcranial Direct Current Stimulation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Participants

Study Groups

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sham tDCS

tDCS delivered for only 30 sec to replicate tingling sensation and blind subject

Group Type SHAM_COMPARATOR

sham transcranial direct current stimulation

Intervention Type DEVICE

transcranial direct current stimulation applied at 2 mA over the right parietal region for 30 sec

cathodal tDCS

cathodal tDCS, 2 milliamps (mA), delivered to right parietal region

Group Type EXPERIMENTAL

transcranial direct current stimulation

Intervention Type DEVICE

transcranial direct current stimulation applied at 2 mA over the right parietal region for 20 min

Interventions

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transcranial direct current stimulation

transcranial direct current stimulation applied at 2 mA over the right parietal region for 20 min

Intervention Type DEVICE

sham transcranial direct current stimulation

transcranial direct current stimulation applied at 2 mA over the right parietal region for 30 sec

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Educational attainment of at least eight years and English as the native language
* Mini-Mental State Examination (MMSE) score of 26
* Normal episodic memory (i.e., CERAD word List Recall \> 5)
* Informed consent; 5) age of 20-30

Exclusion Criteria

* Disturbed consciousness
* Other neurological or systemic disorder which can cause dementia or cognitive dysfunction
* Prior history of a major psychiatric disorder
* History of definite stroke
* Focal lesion on MRI exam
* Use of anxiolytic, antidepressant, neuroleptic, or sedative medication
* Predominately left-handed
* Has MRI contraindication such as pacemaker, implanted pumps, shrapnel, etc. (full MRI screening form will be filled out).
Minimum Eligible Age

20 Years

Maximum Eligible Age

30 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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National Institute on Aging (NIA)

NIH

Sponsor Role collaborator

Johns Hopkins University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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John Desmond

Role: PRINCIPAL_INVESTIGATOR

Johns Hopkins University

Other Identifiers

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R01AG021501

Identifier Type: NIH

Identifier Source: secondary_id

View Link

NA_00045404

Identifier Type: -

Identifier Source: org_study_id

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