Effects of Transcranial Magnetic Stimulation to the Cerebellum on Cognition

NCT ID: NCT00740701

Last Updated: 2018-08-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

17 participants

Study Classification

INTERVENTIONAL

Study Start Date

2000-04-30

Study Completion Date

2005-01-31

Brief Summary

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Functional neuroimaging studies have shown that the cerebellum is active during cognitive performance. The investigators hypothesize that stimulation of the cerebellum with transcranial magnetic stimulation will produce brief changes in performance of the task, suggesting that cerebellar activation is necessary for normal cognitive function.

Detailed Description

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Conditions

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Cognitive Performance

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Participants

Study Groups

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Sham TMS

A Sham TMS coil, designed to elicit sham cerebellar transcranial magnetic stimulation, is used to administer sham TMS pulses after letters are presented.

Group Type SHAM_COMPARATOR

Cerebellar transcranial magnetic stimulation

Intervention Type DEVICE

single pulse TMS or repetitive TMS at 1 Hz frequency

TMS

A genuine TMS coil is used to administer cerebellar transcranial magnetic stimulation pulses after letter presentation.

Group Type EXPERIMENTAL

Cerebellar transcranial magnetic stimulation

Intervention Type DEVICE

single pulse TMS or repetitive TMS at 1 Hz frequency

Interventions

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Cerebellar transcranial magnetic stimulation

single pulse TMS or repetitive TMS at 1 Hz frequency

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* 19-30 years of age
* Informed consent

Exclusion Criteria

* History of seizure or a family history of epilepsy
* History of stroke
* Presence of metal anywhere in the head except the mouth
* Presence of cardiac pacemakers
* Presence of cochlear implants
* Presence of implanted medication pump
* History of heart disease
* Presence of intracardiac lines
* Increased intracranial pressure, such as after infarctions or trauma
* Children, or outside of age range
* Pregnancy
* Currently taking tricyclic anti-depressants or neuroleptic medication
* History of head trauma
* History of respiratory disease
Minimum Eligible Age

19 Years

Maximum Eligible Age

30 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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National Institute of Mental Health (NIMH)

NIH

Sponsor Role collaborator

National Institute on Aging (NIA)

NIH

Sponsor Role collaborator

Johns Hopkins University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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John E Desmond, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

Johns Hopkins University

Locations

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Kennedy Krieger Institute

Baltimore, Maryland, United States

Site Status

Countries

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United States

Other Identifiers

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R01MH060234

Identifier Type: NIH

Identifier Source: secondary_id

View Link

NA_00044841

Identifier Type: -

Identifier Source: org_study_id

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