Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
80 participants
INTERVENTIONAL
2017-05-02
2018-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
BASIC_SCIENCE
DOUBLE
Study Groups
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MCI-active
Patients will receive verum tDCS over the angular gyrus on five consecutive days.
active tDCS
Participants will receive active tDCS over the angular gyrus on five consecutive days
MCI-sham
Patients will receive sham tDCS over the angular gyrus on five consecutive days.
sham tDCS
Participants will receive sham tDCS over the angular gyrus on five consecutive days
Healthy Old-active
Participants will receive verum tDCS over the angular gyrus on five consecutive days.
active tDCS
Participants will receive active tDCS over the angular gyrus on five consecutive days
Healthy old-sham
Participants will receive sham tDCS over the angular gyrus on five consecutive days.
sham tDCS
Participants will receive sham tDCS over the angular gyrus on five consecutive days
Interventions
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active tDCS
Participants will receive active tDCS over the angular gyrus on five consecutive days
sham tDCS
Participants will receive sham tDCS over the angular gyrus on five consecutive days
Eligibility Criteria
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Inclusion Criteria
* Diagnosis of MCI based on the latest research criteria (clinical assessment at the memory clinic (prof. Frans RJ Verhey): presence of at least a memory impairment, memory complaints expressed by the patient or informant, no problems in daily life functioning, no dementia and presence of biomarkers (Albert et al., 2011)
* Clinical Dementia Rating score of 0.5 (CDR distinguishes a stage of questionable dementia (CDR 0.5) from people termed healthy (CDR 0) and those with mild dementia (CDR 1)
* Mini-Mental State Examination (MMSE) 23 and being mentally competent (in general, individuals with a MMSE 18 are considered mentally competent)
* Age: between 60 and 85 years old
* 50% female
* Right-handedness
* Average level of education (CBS level 3-4-5-6)
Healthy controls
* Average neuropsychological test results, in accordance with normative data, corrected for age, education and gender
* No substantial memory complaints (according to the participant)
* Age: between 60 and 85 years old
* 50% female
* Right-handedness
* Average level of education (CBS level 3-4-5-6)
* Normal or corrected to normal vision
Exclusion Criteria
* Abuse of alcohol and drugs
* Cognitive impairment due to alcohol/drug abuse or abuse of other substances
* Past or present psychiatric or neurological disorders (major depression, schizophrenia, bipolar disorder, psychotic disorder (or treatment for it), epilepsy, stroke, Parkinson's disease, multiple sclerosis, brain surgery, brain trauma, electroshock therapy, kidney dialysis, Menière's disease, brain infections)
* Major vascular disorders (e.g. stroke)
* Heart diseases or pacemakers
* Contraindications for scanning (e.g. brain surgery, cardiac pacemaker, metal implants, claustrophobia, body tattoos)
* Large scars or fresh wounds on the scalp
60 Years
85 Years
ALL
Yes
Sponsors
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Maastricht University Medical Center
OTHER
Responsible Party
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Principal Investigators
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Heidi IL Jacobs, PhD
Role: PRINCIPAL_INVESTIGATOR
Maastricht University
Frans RJ Verhey, Professor
Role: STUDY_CHAIR
Maastricht University
Locations
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Maastricht University
Maastricht, Limburg, Netherlands
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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NL57751.068.16
Identifier Type: -
Identifier Source: org_study_id
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