Effects of Peripheral Magnetic Stimulation on Cortical Excitability in Healthy Individuals
NCT ID: NCT07025759
Last Updated: 2025-06-17
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
PHASE1
18 participants
INTERVENTIONAL
2022-10-01
2025-10-31
Brief Summary
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Detailed Description
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Participants: Healthy adults (18-40 years) undergo pre-/post-intervention assessments: cortical (MEPs, ICI/ICF) excitability.
Design: Crossover, double-blind.
Analysis: ANOVA or Friedman tests (SPSS v20.0; α=0.05).
Significance: Clarifies parameter-specific neuromodulatory effects, guiding future rehabilitation protocols for neurological conditions.
Ethics: Approved by Federal University of Pernambuco's ethics committee (Resolution 466/12). Data stored securely for 5 years.
Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
DOUBLE
Study Groups
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Peripheral magnetic stimulation (90% + 1 Hz)
Peripheral magnetic stimulation (90% of RMT + 1 Hz)
Low-frequency stimulation (1 Hz) at 90% of resting motor threshold intensity, delivering a total of 2400 pulses.
Peripheral magnetic stimulation (100% + 25 Hz)
Peripheral magnetic stimulation (100% of RMT + 25 Hz)
High-frequency (25 Hz), at resting motor threshold intensity (100%) protocol delivering 2400 pulses.
Peripheral magnetic stimulation (90% + 25 Hz)
Peripheral magnetic stimulation (90% of RMT + 25 Hz)
High-frequency stimulation (25 Hz) at 90% of resting muscle threshold intensity, with 2400 pulses.
Peripheral magnetic stimulation (100% + 1 Hz)
Peripheral magnetic stimulation (100% of RMT + 1 Hz)
Low-frequency (1 Hz), at resting motor threshold intensity (100%) protocol delivering 2400 pulses.
Peripheral magnetic stimulation (100% + 10 Hz)
Peripheral magnetic stimulation (100% of RMT + 10 Hz)
High-frequency (10 Hz), at resting motor threshold intensity (100%) protocol delivering 2400 pulses.
Peripheral magnetic stimulation (110% + 1 Hz)
Peripheral magnetic stimulation (110% of RMT + 1Hz)
Low-frequency (1 Hz), above resting motor threshold intensity (110%) protocol delivering 2400 pulses.
Peripheral magnetic stimulation (110% + 10 Hz)
Peripheral magnetic stimulation (110% of RMT + 10Hz)
High-frequency (10 Hz), above resting motor threshold intensity (110%) protocol delivering 2400 pulses.
Peripheral magnetic stimulation (110% + 25 Hz)
Peripheral magnetic stimulation (110% of RMT + 25Hz)
High-frequency (25 Hz), above resting motor threshold intensity (110%) protocol delivering 2400 pulses.
Peripheral magnetic stimulation (90% + 10 Hz)
Peripheral magnetic stimulation (90% of RMT + 10 Hz)
High-frequency stimulation (10 Hz) at 90% of resting motor threshold intensity, totaling 2400 pulses.
Interventions
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Peripheral magnetic stimulation (90% of RMT + 1 Hz)
Low-frequency stimulation (1 Hz) at 90% of resting motor threshold intensity, delivering a total of 2400 pulses.
Peripheral magnetic stimulation (90% of RMT + 10 Hz)
High-frequency stimulation (10 Hz) at 90% of resting motor threshold intensity, totaling 2400 pulses.
Peripheral magnetic stimulation (90% of RMT + 25 Hz)
High-frequency stimulation (25 Hz) at 90% of resting muscle threshold intensity, with 2400 pulses.
Peripheral magnetic stimulation (100% of RMT + 1 Hz)
Low-frequency (1 Hz), at resting motor threshold intensity (100%) protocol delivering 2400 pulses.
Peripheral magnetic stimulation (100% of RMT + 10 Hz)
High-frequency (10 Hz), at resting motor threshold intensity (100%) protocol delivering 2400 pulses.
Peripheral magnetic stimulation (100% of RMT + 25 Hz)
High-frequency (25 Hz), at resting motor threshold intensity (100%) protocol delivering 2400 pulses.
Peripheral magnetic stimulation (110% of RMT + 1Hz)
Low-frequency (1 Hz), above resting motor threshold intensity (110%) protocol delivering 2400 pulses.
Peripheral magnetic stimulation (110% of RMT + 10Hz)
High-frequency (10 Hz), above resting motor threshold intensity (110%) protocol delivering 2400 pulses.
Peripheral magnetic stimulation (110% of RMT + 25Hz)
High-frequency (25 Hz), above resting motor threshold intensity (110%) protocol delivering 2400 pulses.
Eligibility Criteria
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Inclusion Criteria
Exclusion criteria: Pregnancy; history of seizures or epilepsy; metallic implants in the head, spine, face, or heart; diagnosed neurological or musculoskeletal conditions interfering with assessments or interventions; or use of substances altering nervous system excitability.
18 Years
40 Years
ALL
Yes
Sponsors
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Universidade Federal de Pernambuco
OTHER
Responsible Party
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Kátia Monte-Silva
Professor
Locations
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Universidade Federal de Pernambuco
Recife, Pernambuco, Brazil
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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Parameters_pMS
Identifier Type: -
Identifier Source: org_study_id
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