Cortical Excitability Using Robotised and Neuronavigated Transcranial Magnetic Stimulation
NCT ID: NCT02168413
Last Updated: 2021-12-08
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
144 participants
OBSERVATIONAL
2014-05-14
2021-05-12
Brief Summary
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* to develop the cortcial excitbality (CE) measurement methodology using coupling between transcranial magnetic stimulation (TMS) and physiological recordings such as electroencephalography (EEG) and electromyography (EMG),
* to automatize these measurements using robotized TMS.
Assessing CE is a preliminary and crucial step in any TMS protocol, in either fundamental or clinical research. It is an important indicator which determine the stimulation power applied on the cortical target during the TMS experiment, or during the rTMS cure (patients). CE is in general measured on the motor cortex using EMG activity as the main indicator of the system's response, whatever the real cortical target is located. The present study thus propose to generalize this measurement on other cortical areas in link with the actual targets, and using other external recordings such as EEG. Moreover, as neuronavigation systems significantly improved TMS precision in the past years, CE measurements could significantly gain to become fully automatized using robotized TMS.
Detailed Description
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CRITERIA OF INCLUSION
* Major Topic (18 to 75)
* Signed informed consent,
* A medical examination must be done before participation in research,
* Membership or beneficiary of a social security scheme,
CRITERIA OF NON-INCLUSION
* Topic of under 18 and over 75 years.
* Against-indications (CI) to the practice of MRI pacemaker or implantable defibrillator or pacemaker neurosensory (risk of temporary or permanent damage to the device or heating metal parts). Cochlear implants (risk of demagnetization, electrode temperature rise and artifacts). Ocular or cerebral ferromagnetic foreign body close to the nerve structures (risk of displacement and complications such as eye or brain damage). Metal prostheses (possibility of significant artifacts according to their size and their ferromagnetic character, some neurosurgical clips or heart valves can cause problems and require an investigation into the exact model implanted). Topics claustrophobic. Pregnant woman. Neurosurgical ventriculoperitoneal bypass valves. Irremovable metal braces.
* CI practice of TMS: the history of epilepsy or seizures during hyperthermia during childhood are related ICs. Ferrométalliques body presence in the brain, cochlear implants, pacemakers, insulin pumps, during pregnancy, about jet lag or not having slept the night before the session of TMS.
* Existence of a severe condition in general terms: cardiac, respiratory, hematologic, renal, hepatic, cancerous,
* Regular Taking anxiolytics, sedatives, antidepressants, neuroleptics,
* Psychiatric disorder characterized,
* Alcohol ingestion before the examination,
* Persons referred to in Articles L1121-5 to L1121-8 CSP.
Conditions
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Keywords
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Study Design
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COHORT
PROSPECTIVE
Eligibility Criteria
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Inclusion Criteria
* consent form signed
* medical examination done prior to the experiment
* affiliated to the French social security
18 Years
75 Years
ALL
Yes
Sponsors
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Centre National de la Recherche Scientifique, France
OTHER
University Hospital, Grenoble
OTHER
Responsible Party
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Principal Investigators
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Thierry BOUGEROL, PUPH
Role: PRINCIPAL_INVESTIGATOR
University Hospital, Grenoble
Locations
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UMS CNRS 3552 IRMaGe
Grenoble, RA, France
Countries
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Other Identifiers
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2013-A01734-41
Identifier Type: -
Identifier Source: org_study_id