Neuroendocrine Mapping of the Cerebral Cortex

NCT ID: NCT04183153

Last Updated: 2021-10-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Clinical Phase

NA

Study Classification

INTERVENTIONAL

Study Start Date

2020-08-31

Study Completion Date

2025-12-31

Brief Summary

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This study is investigating brain regions that share functional connectivity with the hypothalamus and the stimulation of those regions using repetitive transcranial magnetic stimulation (rTMS) to activate the hypothalamus indirectly. The goal of this study is to determine the effectiveness of rTMS in influencing the hypothalamus to better understand the mechanisms between it and the neuroendocrine processes it controls.

Detailed Description

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Conditions

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Healthy

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Healthy Arm

Group Type EXPERIMENTAL

Repetitive Transcranial Magnetic Stimulation

Intervention Type DEVICE

Participants will receive repetitive transcranial magnetic stimulation (rTMS) to determine if stimulating areas with activating functional connectivity will activate the hypothalamus and in turn, have a measurable effect on hormone levels.

Interventions

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Repetitive Transcranial Magnetic Stimulation

Participants will receive repetitive transcranial magnetic stimulation (rTMS) to determine if stimulating areas with activating functional connectivity will activate the hypothalamus and in turn, have a measurable effect on hormone levels.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Age: 21-55
* Gender: Females and Males
* Weight: Less than 280 pounds
* Mobile
* Normal vision with corrective lenses if necessary
* Fluent in English (written and spoken)

Exclusion Criteria

* History of epilepsy/seizures (including history of withdrawal/provoked seizures)
* Metal implant in brains (e.g. deep stimulation), cardiac pacemaker, or cochlear implants
* Shrapnel or any ferromagnetic item in the head
* Showing symptoms of withdrawal from alcohol or benzodiazepines
* Current severe insomnia (must sleep a minimum of 4 hours the night before stimulation)
* Migraine or significant headaches
* Shoulder or neck stiffness
* Over 280 pounds
* In-dwelling ferrous metals
* Left handed
* Abnormal hearing
* Abnormal vision that cannot be corrected with lenses
* Claustrophobia
* Illicit drug use
* Psychotropic medication use
* Marijuana and/or nicotine use
* Psychiatric or neurological conditions
* Endocrine conditions
* History of head trauma with loss of consciousness
Minimum Eligible Age

21 Years

Maximum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Stanford University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Keith Sudheimer, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

Stanford University

Other Identifiers

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53928

Identifier Type: -

Identifier Source: org_study_id

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