The Role of Primary Motor Cortex and Prefrontal Cortex for Facilitation of Motor System and Working Memory

NCT ID: NCT02006615

Last Updated: 2021-01-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

150 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-06-02

Study Completion Date

2021-07-11

Brief Summary

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The investigators hypothesize that ten sessions of repetitive transcranial magnetic stimulation yield ability to upregulate the function of primary motor cortex and prefrontal cortex that play key roles in motor and frontal memory processing.

Detailed Description

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Excitatory (\>3Hz) rTMS could facilitate the brain cortex and neuroplasticity that benefits motor control and working memory when the coil is applied over primary motor cortex or dorsolateral prefrontal gyrus.

Conditions

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Central Nervous System Diseases

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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High frequency rTMS plus fNIRS

rTMS with neuroimage assessment of functional near infrared spectroscopy

Group Type EXPERIMENTAL

Functional near infrared spectroscopy

Intervention Type DEVICE

Using high-sensitivity infrared to detect the active brain areas

rTMS

Intervention Type DEVICE

To modulate brain cortex

Sham rTMS

Sham stimulation

Group Type SHAM_COMPARATOR

rTMS

Intervention Type DEVICE

To modulate brain cortex

High frequency rTMS

High frequency rTMS to modulate brain areas

Group Type EXPERIMENTAL

rTMS

Intervention Type DEVICE

To modulate brain cortex

Interventions

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Functional near infrared spectroscopy

Using high-sensitivity infrared to detect the active brain areas

Intervention Type DEVICE

rTMS

To modulate brain cortex

Intervention Type DEVICE

Other Intervention Names

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fNIRS

Eligibility Criteria

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Inclusion Criteria

1. Ischemic or hemorrhagic cerebrovascular lesion,
2. Parkinson's disease

Exclusion Criteria

* Seizure
* With metal implantation
* Dementia or severe cognitive impairment
Minimum Eligible Age

30 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Taipei Veterans General Hospital, Taiwan

OTHER_GOV

Sponsor Role lead

Responsible Party

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vghtpe user

Principal investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Po-Yi Tsai, MD

Role: PRINCIPAL_INVESTIGATOR

Taipei Veterans General Hospital, Taiwan

Locations

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Taipei Veterans General Hospital

Taipei, , Taiwan

Site Status RECRUITING

Countries

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Taiwan

Central Contacts

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Po-Yi Tsai, MD

Role: CONTACT

886-228757293

Chih-Jou Lai, MD

Role: CONTACT

886-228757361

Facility Contacts

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Po-Yi Tsai, MD

Role: primary

886-228757293

References

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Chang PW, Lu CF, Chang ST, Tsai PY. Functional Near-Infrared Spectroscopy as a Target Navigator for rTMS Modulation in Patients with Hemiplegia: A Randomized Control Study. Neurol Ther. 2022 Mar;11(1):103-121. doi: 10.1007/s40120-021-00300-0. Epub 2021 Nov 13.

Reference Type DERIVED
PMID: 34773596 (View on PubMed)

Tsai PY, Lin WS, Tsai KT, Kuo CY, Lin PH. High-frequency versus theta burst transcranial magnetic stimulation for the treatment of poststroke cognitive impairment in humans. J Psychiatry Neurosci. 2020 Jul 1;45(4):262-270. doi: 10.1503/jpn.190060.

Reference Type DERIVED
PMID: 32159313 (View on PubMed)

Lai CJ, Wang CP, Tsai PY, Chan RC, Lin SH, Lin FG, Hsieh CY. Corticospinal integrity and motor impairment predict outcomes after excitatory repetitive transcranial magnetic stimulation: a preliminary study. Arch Phys Med Rehabil. 2015 Jan;96(1):69-75. doi: 10.1016/j.apmr.2014.08.014. Epub 2014 Sep 11.

Reference Type DERIVED
PMID: 25218256 (View on PubMed)

Related Links

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http://www.ncbi.nlm.nih.gov/pubmed/23194830

Document of rTMS effect in functional facilitation

http://www.ncbi.nlm.nih.gov/pubmed/21980359

Document of rTMS effect in functional facilitation

http://www.ncbi.nlm.nih.gov/pubmed/19309294

Document of rTMS effect in functional facilitation

Other Identifiers

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2013-07-011A

Identifier Type: -

Identifier Source: org_study_id

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