MAP( Mean Arterial Pressure) and Mortality Relation in Patients With Heart Failure

NCT ID: NCT06515366

Last Updated: 2024-07-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

280 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-06-01

Study Completion Date

2025-06-01

Brief Summary

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Aim of this observational study is to evaluate the relationship between mean arterial pressure (MAP) and mortality in patients presenting to the emergency department with acute heart failure, focusing on emergency department monitoring and subgroup presentations. Our goal is to determine the impact of subgroup characteristics on mortality among patients presenting with heart failure in the emergency department, and to assess the predictive value and significance of MAP in predicting mortality.

Detailed Description

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After obtaining ethical approval, the study will commence within 2 weeks and continue for 1 year. Based on clinical statistics or general literature data, and considering sample size calculations, a total of 280 patients across 4 groups have been determined.

Inclusion Criteria:

Age 18 and above Patients presenting with symptoms of heart failure

Exclusion Criteria:

Age under 18 Patients presenting with ST-elevation myocardial infarction Patients with acute kidney failure Pregnant patients Patients with inaccessible data for the parameters under study

Groups based on initial mean arterial pressure (MAP) upon hospital admission will be established as follows: \<65 mmHg, 66-80 mmHg, 81-100 mmHg, \>100 mmHg. Data including results of emergency department tests and pertinent findings will be recorded for patients in these groups. The 30-day mortality rates of these patients will be statistically evaluated based on their MAP values and the procedures performed during emergency department monitoring.

Conditions

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Heart Failure

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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MAP ≤ 65 mmHg

patient having heart failure symptoms with known heart failure and presenting to emergency department with a mean arterial pressure ≤ 65 mmHg

No interventions assigned to this group

MAP 66-80 mmHg

patient having heart failure symptoms with known heart failure and presenting to emergency department with a mean arterial pressure between 66-80 mmHg

No interventions assigned to this group

MAP 81-100 mmHg

patient having heart failure symptoms with known heart failure and presenting to emergency department with a mean arterial pressure between 81-100 mmHg

No interventions assigned to this group

MAP >100 mmHg

patient having heart failure symptoms with known heart failure and presenting to emergency department with a mean arterial pressure between \>100 mmHg

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

Age 18 and above Patients presenting with symptoms of heart failure

Exclusion Criteria

Age under 18 Patients presenting with ST-elevation myocardial infarction Patients with acute kidney failure Pregnant patients Patients with inaccessible data for the parameters under study
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Ankara Etlik City Hospital

OTHER_GOV

Sponsor Role collaborator

Saglik Bilimleri Universitesi

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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gulsen akcay, ass. prof.

Role: STUDY_DIRECTOR

ass. prof. of organization

Locations

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Etlik City Hospital

Ankara, Yenimahalle, Turkey (Türkiye)

Site Status RECRUITING

Countries

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Turkey (Türkiye)

Central Contacts

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gulsen akcay, ass. prof.

Role: CONTACT

+905052874949

elif hamzacebioglu kayisoglu, specialist

Role: CONTACT

+905453300679

Facility Contacts

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gulsen akcay, ass. prof.

Role: primary

+905052874949

elif hamzacebioglu kayisoglu, specalist

Role: backup

+905453300679

References

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Ma H, Li H, Sheng S, Quan L, Yang Z, Xu F, Zeng W. Mean arterial pressure and mortality in patients with heart failure: a retrospective analysis of Zigong heart failure database. Blood Press Monit. 2023 Dec 1;28(6):343-350. doi: 10.1097/MBP.0000000000000674. Epub 2023 Sep 14.

Reference Type BACKGROUND
PMID: 37702595 (View on PubMed)

Burstein B, Tabi M, Barsness GW, Bell MR, Kashani K, Jentzer JC. Association between mean arterial pressure during the first 24 hours and hospital mortality in patients with cardiogenic shock. Crit Care. 2020 Aug 20;24(1):513. doi: 10.1186/s13054-020-03217-6.

Reference Type BACKGROUND
PMID: 32819421 (View on PubMed)

Gao Q, Lin Y, Xu R, Zhang Y, Luo F, Chen R, Li P, Nie S, Li Y, Su L. Association between mean arterial pressure and clinical outcomes among patients with heart failure. ESC Heart Fail. 2023 Aug;10(4):2362-2374. doi: 10.1002/ehf2.14401. Epub 2023 May 12.

Reference Type BACKGROUND
PMID: 37177860 (View on PubMed)

Other Identifiers

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MAP and Mortality

Identifier Type: -

Identifier Source: org_study_id

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