Pulsatile and Steady State Hemodynamics in Diastolic Heart Failure

NCT ID: NCT00720525

Last Updated: 2011-07-18

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 362 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2008-04-30
• Study Completion Date: 2011-07-31

Brief Summary

Over the past few years, there has been a growing appreciation that a large number of patients with heart failure have a relatively normal (or preserved) ejection fraction (NFNEF). Epidemiologically, HFNEF is most prevalent among elderly women, most of whom have hypertension, diabetes, or both and often coronary artery disease (CAD). Increased arterial stiffness and/or wave reflections have been described in the same patient groups. Therefore, the investigators speculate that pulsatile hemodynamics, representing arterial stiffness and/or arterial wave reflections, 1) may be altered in HFNEF patients, 2) this may contribute to pathophysiology of HFNEF, and 3) this may be used for the diagnosis of the syndrome.

Conditions

Diastolic Heart Failure

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: PROSPECTIVE

Study Groups

1

Patients with diastolic heart failure

No interventions assigned to this group

2

Patients without diastolic heart failure

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• exertional dyspnea
• undergoing heart catheterization for diagnosis or exclusion of coronary artery disease
• normal EF (> 50%)

Exclusion Criteria

• atrial fibrillation
• more than mild valvular heart disease
• pericardial disease
• no informed consent

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Klinikum Wels-Grieskirchen

OTHER

Sponsor Role: lead

Responsible Party

Cardiology Department, Klinikum Wels-Grieskirchen, Austria

Principal Investigators

Thomas Weber, MD

Role: PRINCIPAL_INVESTIGATOR

Cardiology Department, Klinikum Wels-Grieskirchen, Austria

Locations

Cardiology Department, Klinikum Wels-Grieskirchen

Wels, , Austria

Countries

Austria

References

Weber T, Wassertheurer S, O'Rourke MF, Haiden A, Zweiker R, Rammer M, Hametner B, Eber B. Pulsatile hemodynamics in patients with exertional dyspnea: potentially of value in the diagnostic evaluation of suspected heart failure with preserved ejection fraction. J Am Coll Cardiol. 2013 May 7;61(18):1874-83. doi: 10.1016/j.jacc.2013.02.013. Epub 2013 Mar 6.

Reference Type: DERIVED

PMID: 23500307 (View on PubMed)

Other Identifiers

EK 248

Identifier Type: -

Identifier Source: org_study_id