Study of Polymorphisms of RAAS and MMPs in Acute Heart Failure
NCT ID: NCT02170961
Last Updated: 2020-08-11
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
300 participants
OBSERVATIONAL
2013-02-28
2016-12-31
Brief Summary
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* association of RAAS polymorphisms and AHF
* association of MMP 3 and 12 polymorphisms and AHF
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Detailed Description
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The renin angiotensin aldosterone system governs the salt and water homeostasis in the body. Renin is a proteolytic enzyme secreted by the juxtaglomerular apparatus of the kidney (area near the glomeruli). Renin has no direct action on the organism, but that is part of the renin-angiotensin system or the renin-angiotensin-aldosterone system is known.
To date, few published studies have examined the association between the polymorphism AGT M235T \* and cardiac dysfunction; and available results are contradictory. What is not known yet is the ratio of this polymorphism with the prognosis of heart failure.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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acute heart failure (AHF)
patients consulting the emergency department for dyspnea. the diagnosis of AHF was based on clinical, biological (BNP) and echocardiographic data.
No interventions assigned to this group
Non acute heart failure (NAHF)
patients consulting the emergency department for dyspnea. the diagnosis of AHF was based on clinical, biological (BNP) and echocardiographic data.
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* acute non traumatic dyspnea .
Exclusion Criteria
* a history of a heart transplant, pericardial effusion, chest wall deformity suspected of causing dyspnea
* coma, shock,MV,vasopressor drugs
* arrhythmia serious and sustained,
* pace maker
* severe mitral valve disease,
18 Years
ALL
No
Sponsors
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University of Monastir
OTHER
Responsible Party
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Pr. Semir Nouira
Professor
Principal Investigators
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Nouira Samir, Professor
Role: PRINCIPAL_INVESTIGATOR
University of Monastir
Locations
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Nouira Samir
Monastir, Emergency Department Monastir, Tunisia 5000, Tunisia
Countries
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Related Links
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official website
Other Identifiers
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PRA-MMP
Identifier Type: -
Identifier Source: org_study_id
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