Study of the Clinical Scoring System and Cytokines for Prediction of Inflammatory Response in Major Surgery

NCT ID: NCT01353157

Last Updated: 2011-05-12

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 20 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2010-03-31
• Study Completion Date: 2010-12-31

Brief Summary

Cardiac surgery with cardiopulmonary bypass (CPB) and hepatic surgery are major operations, associated with a systemic inflammatory response syndrome. The aim of this study is to assess the effectiveness of clinical scoring systems and inflammatory cytokine levels for predicting systemic inflammation. This correlation might identify peri-operative clinical outcomes, then forecast further systemic inflammation in cardiac and hepatic surgical patients.

Detailed Description

Systemic inflammatory response syndrome (SIRS) is commonly found in most major surgery. Early detection of SIRS will lead to early treatment. Serum cytokines levels are reliable markers for SIRS detection but with high cost and inconvenience. Clinical Scoring Systems are commonly used for assessment of patients with SIRS. If they have good correlation with cytokine levels, they might be used to predict peri-operative clinical outcomes.

Conditions

Heart; Dysfunction Postoperative, Cardiac Surgery; Cytokine Release Syndrome

Study Design

• Observational Model Type: CASE_ONLY
• Study Time Perspective: PROSPECTIVE

Study Groups

patients with elective cardiac surgery

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• adult patients who had undergone elective cardiac surgery with CPB

Exclusion Criteria

• under 18 years of age
• needing emergency surgery
• needing intra-aortic balloon pump

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Khon Kaen University

OTHER

Sponsor Role: lead

Responsible Party

Faculty of Medicine, Khon Kaen University

Principal Investigators

Sirirat Tribuddharat, MD

Role: PRINCIPAL_INVESTIGATOR

Faculty of Medicine, Khon Kaen University

Locations

Queen Sirikit Heart Center of the Northeast, Khon Kaen University

Khon Kaen, Changwat Khon Kaen, Thailand

Countries

Thailand

Other Identifiers

HE531033

Identifier Type: -

Identifier Source: org_study_id