Transpulmonary Gradient After Cardiac Surgery Under Cardiopulmonary Bypass

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

30 participants

Study Classification

OBSERVATIONAL

Brief Summary

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Get a better understanding of the pathophysiological processes of acute respiratory failure following cardiopulmonary bypass to initiate timely therapies targeted on a cell line.

Demonstrate that there is a relationship between increased transpulmonary gradients of inflammation biomarkers (sRAGE, sICAM-1, SPB, PAI-1, ROS) and pulmonary vascular resistance on the one hand and alveolo-capillary gas exchange on the other hand after cardiac surgery under cardiopulmonary bypass.

Detailed Description

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Conditions

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Acute Respiratory Distress Syndrome After Cardiac Surgery Under Cardiopulmonary Bypass

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Patient man or woman \> 18 y.o.
* Patient has signed informed consent prior to the study
* Patient affiliated to a social security administration
* Patient operated on for cardiac surgery at the University Hospital of Strasbourg.
* Patient at high risk for postoperative respiratory failure defined by a SLIP score (Kor et al.) ≥ 22 Kor:

* High-risk cardiac intervention under cardiopulmonary bypass (19 pts)
* COPD (10 pts)
* Diabetes (6 pts)
* gastroesophageal reflux (7 pts)
* Alcohol abuse (11 pts)
* Scheduled use of a pulmonary artery catheter and a left atrial catheter

Exclusion Criteria

* Inability to obtain informed consent from the patient and / or unable to give informed patient information (difficulty understanding ...)
* Urgent surgery (\<24h)
* Acute heart failure
* Patient ventilated preoperatively
* Allergy to Latex
* Persons deprived of liberty or under judicial protection
* Patient placed under guardianship
* Pregnancy
* Breastfeeding

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Responsible Party

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Responsibility Role SPONSOR

Locations

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University Hospital

Strasbourg, Alsace, France

Site Status

Countries

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France

Central Contacts

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Julien POTTECHER, MD

Role: CONTACT

Phone: 03 88 12 70 95

Email: [email protected]

Other Identifiers

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5328

Identifier Type: -

Identifier Source: org_study_id