Distribution of Pulmonary Ventilation in Lateral Decubitus of Healthy Adults Under Non-Invasive Mechanical Ventilation

NCT ID: NCT06489509

Last Updated: 2024-07-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-12-06

Study Completion Date

2018-07-08

Brief Summary

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The aim was to investigate via impedance tomography apparatus the distribution of pulmonary ventilation at a lateral position at different Continuous Positive Airway Pressure levels (0, 5, 10 cm Η2Ο) in healthy subjects.

Detailed Description

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In lateral decubitus, the largest percentage of pulmonary ventilation of non-sedated subjects is distributed mainly in the dependent lung. The aim It was to investigate via impedance tomography apparatus the distribution of pulmonary ventilation at a lateral position at different Continuous Positive Airway Pressure levels (0, 5, 10 cm Η2Ο) in healthy subjects. The volunteers were noninvasively ventilated in both lateral positions and supine positions at the beginning and end of the process. It is concluded that implementing Non-Invasive Ventilation in the lateral body position resulted in increased ventilation of the dependent lung. In contrast, the respective ventilation of the non-dependent lung was further decreased.

Conditions

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Noninvasive Ventilation Patient Positioning

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

The regional distribution of pulmonary ventilation was measured in the supine, right, and left lateral positions while alternating the sides to ensure randomization.
Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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Supine position

Supine experimental position

Group Type ACTIVE_COMPARATOR

Positive End Expiratory Pressure 5 H2O

Intervention Type DEVICE

Positive End Expiratory Pressure 5 H2O from CPAP apparatus

Positive End Expiratory Pressure 10 H2O

Intervention Type DEVICE

Positive End Expiratory Pressure 5 H2O from CPAP apparatus

Right position

Right lateral decubitus

Group Type ACTIVE_COMPARATOR

Positive End Expiratory Pressure 5 H2O

Intervention Type DEVICE

Positive End Expiratory Pressure 5 H2O from CPAP apparatus

Positive End Expiratory Pressure 10 H2O

Intervention Type DEVICE

Positive End Expiratory Pressure 5 H2O from CPAP apparatus

Left position

Left lateral decubitus

Group Type ACTIVE_COMPARATOR

Positive End Expiratory Pressure 5 H2O

Intervention Type DEVICE

Positive End Expiratory Pressure 5 H2O from CPAP apparatus

Positive End Expiratory Pressure 10 H2O

Intervention Type DEVICE

Positive End Expiratory Pressure 5 H2O from CPAP apparatus

Interventions

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Positive End Expiratory Pressure 5 H2O

Positive End Expiratory Pressure 5 H2O from CPAP apparatus

Intervention Type DEVICE

Positive End Expiratory Pressure 10 H2O

Positive End Expiratory Pressure 5 H2O from CPAP apparatus

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

• Healthy Volunteers

Exclusion Criteria

* Chronic respiratory disease
* BMI\>40
* Smoking history
Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Attikon Hospital

OTHER

Sponsor Role lead

Responsible Party

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Konstantinos Grigoriadis

Chief of allied health professions

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Konstantinos Grigoriadis, Dr

Role: PRINCIPAL_INVESTIGATOR

PT, Attikon University Hospital

Anna Grigoriadou, MSc

Role: STUDY_DIRECTOR

PT, Attikon University Hospital

Frantzeska Frantzeskaki

Role: STUDY_DIRECTOR

MD, Attikon University Hospital

Ioannis Efstathiou

Role: STUDY_DIRECTOR

PT, Attikon University Hospital

Iraklis Tsangaris

Role: STUDY_CHAIR

Professor, Attikon University Hospital

Locations

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Attikon University Hospital

Athens, Attica, Greece

Site Status

Grigoriadis Konstantinos

Athens, Attica, Greece

Site Status

Countries

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Greece

References

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Schnidrig S, Casaulta C, Schibler A, Riedel T. Influence of end-expiratory level and tidal volume on gravitational ventilation distribution during tidal breathing in healthy adults. Eur J Appl Physiol. 2013 Mar;113(3):591-8. doi: 10.1007/s00421-012-2469-7. Epub 2012 Aug 8.

Reference Type BACKGROUND
PMID: 22872368 (View on PubMed)

Sharma JP, Salhotra R, Kumar S, Tyagi A, Sethi AK. Noninvasive lung recruitment maneuver prevents reintubation and reduces ICU stay. Lung India. 2016 Jan-Feb;33(1):99-101. doi: 10.4103/0970-2113.173070. No abstract available.

Reference Type BACKGROUND
PMID: 26933321 (View on PubMed)

Hurewitz AN, Susskind H, Harold WH. Obesity alters regional ventilation in lateral decubitus position. J Appl Physiol (1985). 1985 Sep;59(3):774-83. doi: 10.1152/jappl.1985.59.3.774.

Reference Type RESULT
PMID: 4055566 (View on PubMed)

Lobo B, Hermosa C, Abella A, Gordo F. Electrical impedance tomography. Ann Transl Med. 2018 Jan;6(2):26. doi: 10.21037/atm.2017.12.06.

Reference Type RESULT
PMID: 29430443 (View on PubMed)

Miura MC, Ribeiro de Carvalho CR, Yamada da Silveira LT, de Moraes Regenga M, Petri Damiani L, Fu C. The effects of recruitment maneuver during noninvasive ventilation after coronary bypass grafting: A randomized trial. J Thorac Cardiovasc Surg. 2018 Dec;156(6):2170-2177.e1. doi: 10.1016/j.jtcvs.2018.05.004. Epub 2018 May 28.

Reference Type RESULT
PMID: 29945735 (View on PubMed)

Nishimura M. Electrical Impedance Tomography: The Promise of Noninvasive Lung Images at the Bedside. Respir Care. 2020 Mar;65(3):402-403. doi: 10.4187/respcare.07716. No abstract available.

Reference Type RESULT
PMID: 32086337 (View on PubMed)

Other Identifiers

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EBD2878

Identifier Type: -

Identifier Source: org_study_id

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