Determine the Effect of Prone Positioning in Adults With ARDS by Electrical Impedance Tomography

NCT ID: NCT04725227

Last Updated: 2021-01-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

20 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-12-01

Study Completion Date

2022-12-31

Brief Summary

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determine the effect of prone positioning on ventilation and perfusion distribution in adults with acute respiratory distress syndrome by electrical impedance tomography

Detailed Description

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By intravenous injection of a small amount of normal saline, electrical impedance tomography enables evaluation of the pulmonary blood flow. EIT might be helpful in establishing the hypoxemia etiology at bedside via combining regional ventilation and perfusion information. The objective of this study was to describe the physiological effects of prone position on respiratory mechanics, ventilation and pulmonary perfusion in patients with ARDS.

Conditions

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ARDS Prone Position Electrical Impedance Tomography

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* patients who were undergoing mechanical ventilation with moderate-to-severe ARDS (defined as a Pao2:Fio2 ratio \< 150 mm Hg with a positive end-expiratory pressure ≥ 5 cm of water, and an Fio2 of ≥ 0.6) according to the Berlin definition

Exclusion Criteria

* contraindications to the use of EIT (e.g., presence of pacemaker or chest surgical wounds dressing)
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Shanghai Zhongshan Hospital

OTHER

Sponsor Role lead

Responsible Party

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Ming Zhong

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Ming Zhong, MD, phD

Role: PRINCIPAL_INVESTIGATOR

Fudan University

Locations

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Zhongshan Hospital of Fudan University

Shanghai, Shanghai Municipality, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Ming Zhong, MD, phD

Role: CONTACT

021-65642662

Facility Contacts

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Ming Zhong, MD, phD

Role: primary

References

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Wang Y, Muhetaer Y, Zheng X, Wu W, Tao J, Zhu L, Song J, Zhao Z, Zhong M. Time-dependent effects of prone position on ventilation-perfusion matching assessed by electrical impedance tomography in patients with COVID-19 ARDS: sub-analysis of a prospective physiological study. Ann Intensive Care. 2025 Mar 31;15(1):46. doi: 10.1186/s13613-025-01452-0.

Reference Type DERIVED
PMID: 40163279 (View on PubMed)

Wang Y, Song J, Lin S, Zheng X, Zhao Z, Zhong M. Influence of Prone Position on Regional Ventilation/Perfusion Matching in Patients With ARDS Over Time. Respir Care. 2025 Jul;70(7):821-829. doi: 10.1089/respcare.12247. Epub 2025 Mar 5.

Reference Type DERIVED
PMID: 40040422 (View on PubMed)

Wang YX, Zhong M, Dong MH, Song JQ, Zheng YJ, Wu W, Tao JL, Zhu L, Zheng X. Prone positioning improves ventilation-perfusion matching assessed by electrical impedance tomography in patients with ARDS: a prospective physiological study. Crit Care. 2022 May 27;26(1):154. doi: 10.1186/s13054-022-04021-0.

Reference Type DERIVED
PMID: 35624489 (View on PubMed)

Other Identifiers

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P-E

Identifier Type: -

Identifier Source: org_study_id

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