Improvement of ARDS Ventilation-perfusion Matching by Prone Positioning Assessed by EIT

NCT ID: NCT05765760

Last Updated: 2025-06-15

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 77 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2023-04-01
• Study Completion Date: 2025-05-31

Brief Summary

Acute Respiratory Distress Syndrome (ARDS) is a highly lethal disease with limited treatment options. In recent years, prone position ventilation has been shown to improve the mortality rate and lung injury of ARDS patients by promoting lung recruitment, improving ventilation/perfusion (V/Q) ratio, enhancing respiratory system compliance, promoting sputum drainage, and effectively avoiding overinflation of the dorsal lung. Electrical Impedance Tomography (EIT) technology has been used to evaluate the effect of prone position ventilation on lung V/Q matching, and some studies have confirmed that prone position ventilation can improve lung V/Q matching and oxygenation index. However, previous studies were mostly case reports or small-sample physiological studies that lacked dynamic changes in lung V/Q matching during repeated prone position ventilation. Therefore, this study hypothesizes that prone position ventilation can increase lung V/Q matching in ARDS patients, and its improvement is correlated with changes in oxygenation index, invasive ventilation time, and patient prognosis. Repeated prone position ventilation can maintain lung V/Q matching at a higher level, no longer affected by changes in body position, which can accelerate pulmonary function recovery and improve the prognosis of ARDS patients.

Conditions

Acute Respiratory Distress Syndrome; Prone Position; Electrical Impedance Tomography

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Eligibility Criteria

Inclusion Criteria

1. Age ≥ 18 years old;

2. meet the diagnostic criteria of Berlin's definition for ARDS;

3. invasive ventilation time < 48h;

4. PaO2/FiO2 < 150mmHg.

Exclusion Criteria

1. Contraindication to the prone position;

2. Contraindication to the EIT;

3. Hemodynamically unstable;

4. Patients with hypernatremia;

5. Patients have received extracorporeal membrane oxygenation treatment.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Beijing Chao Yang Hospital

OTHER

Sponsor Role: lead

Responsible Party

Rui Wang

Principal Investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Rui Wang, Dr.

Role: STUDY_DIRECTOR

Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China

Locations

Beijing Chao-Yang Hospital

Beijing, Beijing Municipality, China

Countries

China

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Other Identifiers

2022-KE-615

Identifier Type: -

Identifier Source: org_study_id