Electrical Impedance Tomography: Collapse in Dependent Areas as a Predictor of Response to Prone Position Ventilation in COVID-19 Acute Respiratory Distress Syndrome

NCT ID: NCT04603755

Last Updated: 2021-09-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-10-26

Study Completion Date

2021-03-18

Brief Summary

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There are several clinical presentations of SARS-CoV-2 infection. Among the severe forms, pulmonary involvement with respiratory failure is common. Although severe lung involvement with SARS-CoV-2 meets the Berlin criteria for Acute Respiratory Distress Syndrome (ARDS), it differs from classic ARDS in that compliance (reflecting distensibility of the lung parenchyma) is frequently preserved.

If the interest of Electrical Impedance Tomography has been demonstrated in classical ARDS, this is not the case in ARDS with COVID-19.

However, the use of this technique in this particular patient population would make it possible to distinguish patients with severe hypoxemia linked to derecruitment from those without derecruitment, in whom hypoxemia is more likely to be linked to the loss of hypoxic vasoconstriction.

Detailed Description

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Conditions

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SARS-CoV Infection Acute Respiratory Distress Syndrome

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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Electrical Impedance tomography

Electrical Impedance tomography recording during 5 minutes every day during 7 days

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Patients admitted to the intensive care unit for SARS-CoV-2 ARDS
* Under controlled invasive ventilation for less than 7 days

Exclusion Criteria

* Pneumothorax
* Deformation of the rib cage
* Contraindication to Electrical Impedance Tomography
* Pregnant or breastfeeding woman
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Direction Centrale du Service de Santé des Armées

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Hôpital de la Timone

Marseille, , France

Site Status

Hôpital d'Instruction des Armées Sainte-Anne

Toulon, , France

Site Status

Countries

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France

References

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Cardinale M, Boussen S, Cungi PJ, Esnault P, Mathais Q, Bordes J, Meaudre E, Goutorbe P. Lung-Dependent Areas Collapse, Monitored by Electrical Impedance Tomography, May Predict the Oxygenation Response to Prone Ventilation in COVID-19 Acute Respiratory Distress Syndrome. Crit Care Med. 2022 Jul 1;50(7):1093-1102. doi: 10.1097/CCM.0000000000005487. Epub 2022 Feb 11.

Reference Type DERIVED
PMID: 35200196 (View on PubMed)

Other Identifiers

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2020-A02823-36

Identifier Type: OTHER

Identifier Source: secondary_id

2020-COVID19-16

Identifier Type: -

Identifier Source: org_study_id

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