Comparison of Different PEEP Titration Strategies Using Electrical Impedance Tomography in Patients With ARDS
NCT ID: NCT04247477
Last Updated: 2022-08-02
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
COMPLETED
NA
22 participants
INTERVENTIONAL
2020-09-22
2021-04-08
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
Two of those strategies are based on electrical impedance tomography (EIT) monitoring.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Electrical Impedance Tomography for Optimization of Positive End-Expiratory Pressure: Acute Respiratory Distress Syndrome
NCT03793842
Ventilator-induced Right Ventricular Injury During EIT-based PEEP Titration in Patients With ARDS
NCT05583461
EIT Assessment of Overdistension in ARDS Patients in Prone Position
NCT06536543
Personalized Ventilation Based on Ventilation-perfusion Mismatch and Lung Recruitability
NCT06430554
V/Q Matching Variations With PEEP in ARDS According to Compliance-based Phenotypes (France)
NCT05578742
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
RANDOMIZED
CROSSOVER
A reference strategy, based on the Express method (PEEP level adjusted to reach a plateau pressure of 28-30 cmH2O), is applied at the begining of the study and during a wash-out period (between the 2 periods of application of the 2 EIT-based strategies).
The 2 EIT-based strategies are applied in a randomized order.
TREATMENT
NONE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
A-B-A-C
Four consecutive steps (45 min per step) are tested in the following order: Peep titration strategy according to Express method (A) - Peep titration strategy according to overdistension and collapse estimation (B) - Peep titration strategy according to Express method (A) - Peep titration strategy according to estimation of lung inhomogeneity (C)
Ventilation strategy
Patients are ventilated in randomized order with three different ventilation strategies (A,B and C)
A-C-A-B
Four consecutive steps (45 min per step) are tested in the following order: Peep titration strategy according to Express method (A) - Peep titration strategy according to estimation of lung inhomogeneity (C) - Peep titration strategy according to Express method (A) - Peep titration strategy according to overdistension and collapse estimation (B)
Ventilation strategy
Patients are ventilated in randomized order with three different ventilation strategies (A,B and C)
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
Ventilation strategy
Patients are ventilated in randomized order with three different ventilation strategies (A,B and C)
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* PaO2/FiO2 ratio \< 150 mmHg
* Patient affiliated to or beneficiary of a health care plan
* Consent obtained from patient's SDM
Exclusion Criteria
* Contraindication to the insertion of a nasogastric tube with an esophageal balloon
* Contraindication to the use of Electrical impedance tomography
* Pregnancy, lactating or parturient woman
18 Years
ALL
No
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
University Hospital, Angers
OTHER_GOV
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
CHU Angers
Angers, , France
Countries
Review the countries where the study has at least one active or historical site.
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
49RC19_0249
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.