Evaluation of Regional Ventilation Distribution Using Electrical Impedance Tomography During Weaning From Mechanical Ventilation
NCT ID: NCT05726513
Last Updated: 2023-02-14
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
30 participants
INTERVENTIONAL
2023-02-15
2024-12-31
Brief Summary
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The main question\[s\] it aims to answer are:
* to evaluate which weaning trial is associated to a better regional ventilation distribution
* to evaluate which weaning trial can be comparable to ventilation distribution after extubation
Participants will undergo 3 clinically used weaning trials in a random order (cross-over trial). Researchers will compare the different steps to see if regional ventilation distribution is different among the different trial .
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
DIAGNOSTIC
DOUBLE
Study Groups
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Low support, high Positive end-expiratory pressure
Low support, high Positive end-expiratory pressure
Weaning trial - Low support, high Positive end-expiratory pressure
The researcher will evaluate the readiness to be weaned of the patient using a weaning trial with low pressure support ventilation and a positive end expiratory pressure of 5 cmH2O
Low support, zero positive end-expiratory pressure
Low support, zero positive end-expiratory pressure
Weaning trial - Low support, zero positive end-expiratory pressure
The researcher will evaluate the readiness to be weaned of the patient using a weaning trial with low pressure support ventilation and a positive end expiratory pressure of 0 cmH2O
Zero support, zero positive end-expiratory pressure
Zero support, zero positive end-expiratory pressure
Weaning trial - Zero support, zero positive end-expiratory pressure
The researcher will evaluate the readiness to be weaned of the patient using a weaning trial with 0 pressure support ventilation and a positive end expiratory pressure of 0 cmH2O
Interventions
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Weaning trial - Low support, high Positive end-expiratory pressure
The researcher will evaluate the readiness to be weaned of the patient using a weaning trial with low pressure support ventilation and a positive end expiratory pressure of 5 cmH2O
Weaning trial - Low support, zero positive end-expiratory pressure
The researcher will evaluate the readiness to be weaned of the patient using a weaning trial with low pressure support ventilation and a positive end expiratory pressure of 0 cmH2O
Weaning trial - Zero support, zero positive end-expiratory pressure
The researcher will evaluate the readiness to be weaned of the patient using a weaning trial with 0 pressure support ventilation and a positive end expiratory pressure of 0 cmH2O
Eligibility Criteria
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Inclusion Criteria
* Ready to be weaned from mechanical ventilation according to clinical criteria
Exclusion Criteria
* Presence of chest drains
* Presence of pacemaker/impantable cardiac device;
* diagnosis of Pneumothorax, or pneumomediastinum
* Diagnois of neuromuscular diseases
* Use of neuromuscular blockers in the 48 hours before screening;
* Body mass index \> 35 kg/m2
* Refusal to participate of the patient/next of kin
18 Years
70 Years
ALL
No
Sponsors
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University of Milan
OTHER
Università degli Studi di Ferrara
OTHER
Responsible Party
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Savino Spadaro
Principal investigator
Locations
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Azienda Ospedaliero Universitaria Sant'Anna
Ferrara, , Italy
Countries
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Facility Contacts
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Other Identifiers
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WEAN-EIT
Identifier Type: -
Identifier Source: org_study_id
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