Regional Lung Opening and Closing Pressures in Patients With Acute Lung Injury
NCT ID: NCT01107847
Last Updated: 2010-04-21
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
25 participants
INTERVENTIONAL
Brief Summary
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Detailed Description
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The purpose of this study is to develop a protocol for measuring regional opening and closing pressures using the method of electrical impedance tomography in lung healthy and ALI patients. A ventilator setting guided by regional opening and closing pressures might help reducing the impairment of the lung by artificial ventilation.
Conditions
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Study Design
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PARALLEL
DIAGNOSTIC
NONE
Interventions
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low flow pressure volume manoeuvre
In all patients a standard low flow pressure volume manoeuvre is applied by a respirator with a constant gas flow of 4 l/min starting at a zero end-expiratory pressure up to a tidal volume of 2 l or until a maximum airway pressure of 35 cm H2O was reached.
Eligibility Criteria
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Inclusion Criteria
* acute lung injury / healthy lung (control group)
Exclusion Criteria
* Cerebral trauma / surgery
* Age \< 18 years
* instable cardiovascular disease
* instable chest wall
18 Years
ALL
No
Sponsors
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University Hospital Schleswig-Holstein
OTHER
Responsible Party
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University of Schleswig-Holstein
Principal Investigators
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Jens Scholz, M.D.
Role: STUDY_CHAIR
University Medical Center of Schleswig-Holstein, Campus Kiel, Department of Anesthesiology and Intensive Care Medicine
Locations
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Department of Anesthesiology and Intensive Care Medicine, University Medical Center of Schleswig-Holstein, Campus Kiel
Kiel, , Germany
Countries
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Central Contacts
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Facility Contacts
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References
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Caironi P, Cressoni M, Chiumello D, Ranieri M, Quintel M, Russo SG, Cornejo R, Bugedo G, Carlesso E, Russo R, Caspani L, Gattinoni L. Lung opening and closing during ventilation of acute respiratory distress syndrome. Am J Respir Crit Care Med. 2010 Mar 15;181(6):578-86. doi: 10.1164/rccm.200905-0787OC. Epub 2009 Nov 12.
Wrigge H, Zinserling J, Muders T, Varelmann D, Gunther U, von der Groeben C, Magnusson A, Hedenstierna G, Putensen C. Electrical impedance tomography compared with thoracic computed tomography during a slow inflation maneuver in experimental models of lung injury. Crit Care Med. 2008 Mar;36(3):903-9. doi: 10.1097/CCM.0B013E3181652EDD.
Victorino JA, Borges JB, Okamoto VN, Matos GF, Tucci MR, Caramez MP, Tanaka H, Sipmann FS, Santos DC, Barbas CS, Carvalho CR, Amato MB. Imbalances in regional lung ventilation: a validation study on electrical impedance tomography. Am J Respir Crit Care Med. 2004 Apr 1;169(7):791-800. doi: 10.1164/rccm.200301-133OC. Epub 2003 Dec 23.
Other Identifiers
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UKSH ROP/RCP
Identifier Type: -
Identifier Source: org_study_id
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