Positive Pressure and Gravity Affect Volumetric Capnography

NCT ID: NCT03853057

Last Updated: 2019-02-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-02-01

Study Completion Date

2019-02-21

Brief Summary

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Volumetric capnography is an interesting and non-invasive tool for monitoring ventilation in mechanically ventilated patients. The aim of this study was to test the effect of positive pressure ventilation and different body positions on volumetric capnograms.

Detailed Description

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In this interventional study awake and healthy volunteers will be submitted to spontaneous, pressure support and control pressure ventilation using a tight nasal mask. Volumetric capnography and electrical impedance tomography (EIT) will be continuously recorded during the protocol. Different body positions were randomly tested. Analysis of global and regional distribution of ventilation using EIT will be matched with changes observed in volumetric capnography-derived parameters.

Conditions

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Hypoventilation

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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non-invasive ventilation

Non-invasive positive pressure at different body positions: sitting - supine - prone - right lateral and left lateral.

Group Type EXPERIMENTAL

body positions

Intervention Type OTHER

positive pressure ventilation at different body positions

Interventions

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body positions

positive pressure ventilation at different body positions

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* American Society Anesthesia physical status I.
* Age between 25-39 years old,
* Body mass index between 23-28 kg/m2,
* Non-smokers.

Exclusion Criteria

* Presence of pulmonary or cardiac diseases.
* Abnormal spirometry.
Minimum Eligible Age

28 Years

Maximum Eligible Age

39 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Hospital Privado de Comunidad de Mar del Plata

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Gerardo H Tusman, MD

Role: PRINCIPAL_INVESTIGATOR

Hospital Privado de Comunidad

Locations

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Hospital Privado de Comunidad

Mar del Plata, Buenos Aires, Argentina

Site Status

Countries

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Argentina

References

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Costa EL, Lima RG, Amato MB. Electrical impedance tomography. Curr Opin Crit Care. 2009 Feb;15(1):18-24. doi: 10.1097/mcc.0b013e3283220e8c.

Reference Type BACKGROUND
PMID: 19186406 (View on PubMed)

Tusman G, Scandurra A, Bohm SH, Suarez-Sipmann F, Clara F. Model fitting of volumetric capnograms improves calculations of airway dead space and slope of phase III. J Clin Monit Comput. 2009 Aug;23(4):197-206. doi: 10.1007/s10877-009-9182-z. Epub 2009 Jun 11.

Reference Type BACKGROUND
PMID: 19517259 (View on PubMed)

Other Identifiers

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04112014

Identifier Type: -

Identifier Source: org_study_id

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