LAnguage-Motor Imagery Circuits to Improve Motor Learning and Language Comprehension

NCT ID: NCT06478303

Last Updated: 2024-08-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

105 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-07-27

Study Completion Date

2028-07-26

Brief Summary

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Recent evidence suggests that cognitive systems do not operate in isolation but interact within broader networks, thus opening new avenues for fundamental and clinical research. An illustrative example is the interaction between language comprehension and motor representations. For instance, motor training (e.g., sports, origami training) can facilitate action verb recognition, whereas motor deficits (e.g., upper limb immobilization) can hinder the processing of action language. Similarly, action language has been shown to affect motor performance. These effects are attributed to an implicit form of motor imagery, an automatic simulation of motor experience (without actual movement) evoked by action words. Interestingly, literature supports the idea that the motor simulations used for imagining an action are also engaged during the reading of action language, leading to similar neurophysiological and behavioral changes in both processes. However, questions remain about the similarity of the simulations generated by motor imagery and action language. This project, encompassing three experimental sequences, aims to address these questions to achieve significant scientific advancements in both theoretical and applied domains.

Detailed Description

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Conditions

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Corticospinal Excitability Cortical Activation

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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TMS Experimental group

Motor imagery

Intervention Type OTHER

Participants were asked to imagine arm or foot movements.

Action reading

Intervention Type OTHER

Participants were asked to read sentences involving arm or foot movements

fMRI Experimental group

Motor imagery

Intervention Type OTHER

Participants were asked to imagine arm or foot movements.

Action reading

Intervention Type OTHER

Participants were asked to read sentences involving arm or foot movements

Motor localizer

Intervention Type OTHER

Participants were asked to perform arm or foot movements

Experimental ccPAS group

Motor imagery

Intervention Type OTHER

Participants were asked to imagine arm or foot movements.

Action reading

Intervention Type OTHER

Participants were asked to read sentences involving arm or foot movements

Sham ccPAS group

Motor imagery

Intervention Type OTHER

Participants were asked to imagine arm or foot movements.

Action reading

Intervention Type OTHER

Participants were asked to read sentences involving arm or foot movements

control group

Motor imagery

Intervention Type OTHER

Participants were asked to imagine arm or foot movements.

Action reading

Intervention Type OTHER

Participants were asked to read sentences involving arm or foot movements

Interventions

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Motor imagery

Participants were asked to imagine arm or foot movements.

Intervention Type OTHER

Action reading

Participants were asked to read sentences involving arm or foot movements

Intervention Type OTHER

Motor localizer

Participants were asked to perform arm or foot movements

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* persons who have given written consent,
* healthy subjects
* subjects reading and understanding French
* right-handed,
* affiliated with a social security system,
* between 18 and 40 years old,
* had completed the TMS inclusion questionnaire or had undergone a medical examination prior to participation in the MRI study.

Exclusion Criteria

* Existence of a severe general medical condition: cardiac, respiratory, hematological, renal, hepatic, cancerous,
* Regular use of anxiolytics, sedatives, antidepressants, neuroleptics,
* Characterized psychiatric pathology,
* Ingestion of alcohol prior to the examination,
* Persons covered by articles L1121-5 to L1121-8 of the CSP,
* Presence of contraindications to MRI or TMS.
Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Burgundy

OTHER

Sponsor Role collaborator

University Hospital, Grenoble

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Laurent VERCUEIL

Role: PRINCIPAL_INVESTIGATOR

CHU Grenoble Alpes

Locations

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CHU Grenoble Alpes

Grenoble, Grenob, France

Site Status RECRUITING

Université de Bourgogne

Dijon, , France

Site Status RECRUITING

Countries

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France

Central Contacts

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Laurent VERCUEIL

Role: CONTACT

0476765561

William DUPONT

Role: CONTACT

+33 (0)6 67 76 00 99

Facility Contacts

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Laurent VERCUEIL

Role: primary

+33 (0)4 76 76 55 61

William DUPONT

Role: backup

+33 (0)6 67 76 00 99

Florent LEBON

Role: primary

+33 (0)3 80 39 67 54

William DUPONT

Role: backup

+33 (0)6 67 76 00 99

Other Identifiers

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2023-A02322-43

Identifier Type: OTHER

Identifier Source: secondary_id

38RC23.0349

Identifier Type: -

Identifier Source: org_study_id

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