Effect of Paracetamol and Mannitol Injection on Postoperative Analgesia in Patients With Thoracoscopic Lobectomy
NCT ID: NCT06304181
Last Updated: 2024-03-12
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
NA
90 participants
INTERVENTIONAL
2024-03-15
2024-12-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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Paracetamol and Mannitol Injection group
Paracetamol and Mannitol Injection 500mg was given intravenously 30 minutes before the end of the operation
Paracetamol and Mannitol Injection
Paracetamol and Mannitol Injection 500mg
Parecoxib group
40mg of parecoxib was given intravenously 30min before the end of the operation
Parecoxib
40mg of parecoxib
Interventions
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Paracetamol and Mannitol Injection
Paracetamol and Mannitol Injection 500mg
Parecoxib
40mg of parecoxib
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
2. Patients scheduled for partial lobectomy under thoracoscopy with general anesthesia；
3. Classified as American Society of Anesthesiologists (ASA) physical status I\~II；
4. Age over 18 years；
5. Patients voluntarily participate and sign the informed consent form
Exclusion Criteria
2. heart rate \<50 beats/min；
3. Patients with severe liver or kidney dysfunction (severe liver dysfunction: ALT, conjugated bilirubin, AST, ALP, total bilirubin any one \>2 times the upper limit of normal
4. severe kidney dysfunction: creatinine clearance \<60 ml/min)；
5. Patients with diabetes and complications (diabetic ketoacidosis, hyperosmolar coma, various infections, major vascular changes, diabetic nephropathy, retinopathy, diabetic cardiomyopathy, diabetic neuropathy, diabetic foot, etc.)；
6. Patients with severe pulmonary impairment, such as asthma or chronic obstructive pulmonary disease；
7. History of psychiatric illness or long-term use of psychiatric drugs, chronic pain medication, or history of alcohol abuse；
8. Neuromuscular diseases；
9. Tendency towards malignant hyperthermia；
10. Allergy to the study drug or other contraindications；
11. Participation in another drug clinical trial within the past 30 days；
12. Any cerebrovascular accidents such as stroke, transient ischemic attack (TIA) in the last 3 months；
13. Unstable angina, myocardial infarction in the last 3 months；
14. Undergone another surgery within the last 3 months；
15. Coagulopathy
18 Years
60 Years
ALL
Yes
Sponsors
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The Fourth Affiliated Hospital of Zhejiang University School of Medicine
OTHER
Responsible Party
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Central Contacts
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Other Identifiers
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KY-2023-195
Identifier Type: -
Identifier Source: org_study_id
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