Efficacy of Parecoxib Combined With Paracetamol in Mastectomy
NCT ID: NCT05757388
Last Updated: 2023-04-14
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
60 participants
INTERVENTIONAL
2023-03-28
2023-05-10
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
TRIPLE
Study Groups
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Group P
Receives the parecoxib 40 mg iv slowly push plus paracetamol 1 gm (100 mL) infusion drip in 30 min after induction.
Parecoxib + paracetamol
Administers after induction of anesthesia.
Group C
Receives normal saline in the same process.
Normal saline
Administers after induction of anesthesia.
Interventions
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Parecoxib + paracetamol
Administers after induction of anesthesia.
Normal saline
Administers after induction of anesthesia.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* ASA physical status 1-3
Exclusion Criteria
* History of opioid use
* Pregnant
* Renal or hepatic disease
18 Years
65 Years
FEMALE
No
Sponsors
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Khon Kaen University
OTHER
Responsible Party
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Thepakorn Sathitkarnmanee
Associate professor
Principal Investigators
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Thepakorn Sathitkarnmanee, MD
Role: STUDY_CHAIR
Khon Kaen University
Locations
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Dr. Sirirat Tribuddharat
Khon Kaen, , Thailand
Countries
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Central Contacts
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References
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Kehlet H, Jensen TS, Woolf CJ. Persistent postsurgical pain: risk factors and prevention. Lancet. 2006 May 13;367(9522):1618-25. doi: 10.1016/S0140-6736(06)68700-X.
Woolf CJ, Max MB. Mechanism-based pain diagnosis: issues for analgesic drug development. Anesthesiology. 2001 Jul;95(1):241-9. doi: 10.1097/00000542-200107000-00034. No abstract available.
Schug SA. The role of COX-2 inhibitors in the treatment of postoperative pain. J Cardiovasc Pharmacol. 2006;47 Suppl 1:S82-6. doi: 10.1097/00005344-200605001-00015.
Brett CN, Barnett SG, Pearson J. Postoperative plasma paracetamol levels following oral or intravenous paracetamol administration: a double-blind randomised controlled trial. Anaesth Intensive Care. 2012 Jan;40(1):166-71. doi: 10.1177/0310057X1204000121.
Nonaka T, Hara M, Miyamoto C, Sugita M, Yamamoto T. Comparison of the analgesic effect of intravenous acetaminophen with that of flurbiprofen axetil on post-breast surgery pain: a randomized controlled trial. J Anesth. 2016 Jun;30(3):405-9. doi: 10.1007/s00540-016-2150-0. Epub 2016 Feb 16.
Schug SA, Parsons B, Li C, Xia F. The safety profile of parecoxib for the treatment of postoperative pain: a pooled analysis of 28 randomized, double-blind, placebo-controlled clinical trials and a review of over 10 years of postauthorization data. J Pain Res. 2017 Oct 10;10:2451-2459. doi: 10.2147/JPR.S136052. eCollection 2017.
Other Identifiers
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HE641269
Identifier Type: -
Identifier Source: org_study_id
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