The Influence of Different Anesthesia on Acute and Chronic Postsurgical Pain After Thoracic Surgery

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

600 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-04-01

Study Completion Date

2020-07-30

Brief Summary

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This study would compare acute and chronic postsurgical pain in patients underwent thoracic surgery with different anesthesia and analgesia methods, and explore the influencing factors.

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Detailed Description

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Chronic postsurgical pain (CPSP) was the pain caused by the operation that exceeded the healing time of normal tissue (usually 3 months), that was, a status that the damage caused by noxious stimulus had been healed, but the pain that cannot be explained by disease and inflammation were still existed. Due to the location of the incision and the necessity of indwelling the chest tube, the thoracic lung surgery was considered to be one of the most painful surgical operations. Studies have found that the incidences of CPSP in patients with thoracotomy were 57% (95% CI, 51-64%) and 47% (95% CI, 39-56%) at postoperative 3 and 6 months, respectively. With the development of minimally invasive techniques, thoracic surgery had gradually become less traumatic, and the number of surgical incisions was gradually developed into single port.Through ages, epidural analgesia with a combination of local anesthetics and opioids had long been considered the "gold standard" for postoperative analgesia in thoracic surgery. However, with the development of clinical anesthetics and the widespread use of nerve block techniques, it had been found that in open radical gastrectomy, there was no significant difference in the inhibition of intraoperative stress response between dexmedetomidine combined with general anesthesia and a combined general-epidural anesthesia. So, which anesthesia and analgesia method was "perfect" for a specific type of surgery procedure? This study would compare acute and chronic postsurgical pain in patients underwent different thoracic surgery procedure with different anesthesia and analgesia methods, and explore the influencing factors.

Conditions

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Acute Pain Chronic Postsurgical Pain

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Study Groups

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general anesthesia

patients underwent general anesthesia

No interventions assigned to this group

general and epidural anesthesia

patients underwent general and epidural anesthesia

epidural anesthesia

Intervention Type PROCEDURE

epidural anesthesia

general anesthesia combined with nerve block

patients underwent general anesthesia combined with nerve block

nerve block

Intervention Type PROCEDURE

paravertebral or serratus anterior plane block

Interventions

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epidural anesthesia

Intervention Type PROCEDURE

nerve block

paravertebral or serratus anterior plane block

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* ASA I-II
* underwent selective thoracic surgery

Exclusion Criteria

* with severe cardiac, endocrine,immunologic or haematologic diseases
* medical history of chronic pain problems in chest area
* medical history of pain-relief or sedative medication
* not able to communicate with investigators

Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No