Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
114 participants
OBSERVATIONAL
2024-03-01
2026-10-25
Brief Summary
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Detailed Description
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Endocrine alterations are well characterised in sepsis with variations in circulating blood levels and/or receptor resistance.
In response to any psychological or physical stressor, there is widespread neurohormonal activation to adapt body with the stressor. Production and secretion of stress hormones increase to modulate behaviour Many studies have been performed investigating specific hormonal perturbations such as critical illness-induced corticosteroid insufficiency ,all of which are associated with worse outcomes and poor of body inflammation. However, the endocrine system as a whole has been largely overlooked as a fundamental contributor to the integrated host response to sepsis thyroid axis is affected during sepsis with decreased pituitary release of thyroid stimulating hormone (TSH) and inhibition of the peripheral conversion of thyroxine (T4) by 5-deiodinase to the much more metabolically active triiodothyronine (T3). High cortisol levels also inhibit this enzymatic conversion.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Eligibility Criteria
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Inclusion Criteria
* septic patients admitted to critical care unit
Exclusion Criteria
* hypopituitarism
* Addison disease
* Cushing syndrome)
18 Years
100 Years
ALL
No
Sponsors
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Assiut University
OTHER
Responsible Party
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Sara Mahmoud khalf allah Mohamed
Assistant lecturer
Central Contacts
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References
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Silva MH, Araujo MC, Diniz EM, Ceccon ME, Carvalho WB. Thyroid abnormalities in term infants with fungal sepsis. Rev Assoc Med Bras (1992). 2016 Sep;62(6):561-567. doi: 10.1590/1806-9282.62.06.561.
Other Identifiers
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Thyroid and cortisol in sepsis
Identifier Type: -
Identifier Source: org_study_id
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