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Multiple Biomarkers in ICU Sepsis Patients

NCT ID: NCT03802136

Last Updated: 2019-01-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

120 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-12-30

Study Completion Date

2019-06-30

Brief Summary

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Acute kidney injury (AKI) is a common condition among sepsis patients in the intensive care unit (ICU) and is associated with high morbidity and mortality. Oxidative stress biomarkers were investigated in panels and were reported to predict renal failure in sepsis patients. Some biomarkers would be able to identify who will recover and not recover better than serum creatinine. Thus, a combining oxidative stress biomarkers are needed to predict the occurrence or progression of AKI in critically ill patients.

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Detailed Description

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Acute kidney injury (AKI) is a common condition among sepsis patients in the intensive care unit (ICU) and is associated with high morbidity and mortality. Oxidative stress biomarkers were investigated in panels and were reported to predict renal failure in sepsis patients. Research on AKI has focused on new damage biomarkers for early detection of AKI and worsening of renal function. Some biomarkers would be able to identify who will recover and not recover better than serum creatinine. Thus, a combining functional and damage markers as well as oxidative stress biomarkers are needed to predict the occurrence or progression of AKI in critically ill patients. Therefore, this prospective, observational study will be conducted in Mainland China

Conditions

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Sepsis, Severe Sepsis Septic Shock AKI

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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high concentration of biomarkers

the patients with biomarkers level over the normal max value

No interventions assigned to this group

low concentration of biomarkers

the patients with biomarkers level below the normal max value

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* sepsis patients in appropriate age

Exclusion Criteria

* ever blood transfusion ever CPR（cardiopulmonary resuscitation)
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Zhongnan Hospital

OTHER

Sponsor Role lead

Responsible Party

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ZhiYong Peng

professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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zhiyong peng, professor

Role: STUDY_DIRECTOR

Zhongnan Hospital

Locations

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Zhongnan Hospital of Wuhan University

Wuhan, Hubei, China

Site Status RECRUITING

Countries

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China

Central Contacts

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zhiyong peng, professor

Role: CONTACT

[email protected]
008618672396028

Li He

Role: CONTACT

[email protected]
008617798258617

Facility Contacts

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zhiyong peng, professor

Role: primary

Other Identifiers

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2018062

Identifier Type: -

Identifier Source: org_study_id

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