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Oxidative Stress in Critical Ill Patients in Surgical Intensive Care Unit

NCT ID: NCT00745888

Last Updated: 2009-09-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2007-05-31

Brief Summary

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In clinical practice, the oxidative stress is related to circulatory shock, sepsis, acute lung injury, and acute respiratory distress syndrome. There are some questions on the oxidative stress of the critical illness. First, the investigators want to search out the effects of the past history, smoking, alcohol drinking, use of antioxidants, different diseases, and different duration of SIRS on the degree of oxidative stress. Second, besides total count of ROS, the investigators used new techniques to determine superoxide(O2●-), hydrogen peroxide (H2O2), and hypochlorous acid(HOCl). Furthermore, we want to investigate the correlation of the degree of different reactive oxygen species and the severity of SIRS or shock. Third, we try to investigate the correlation between the change of oxidative stress and the prognosis of the patients.

The investigators wish this study will help them to investigate the effect of oxidative stress on critical ill patients, to modulate the oxidative stress, to decrease the occurrence of SIRS, shock, and multiorgan failure, and to improve the long term outcome of patients.

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Detailed Description

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Conditions

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Sepsis Shock

Study Design

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Study Time Perspective

PROSPECTIVE

Study Groups

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1

age \> 18 y/o Patients admitted to surgical ICU

Chemiluminescence Analyzer

Intervention Type OTHER

measure reactive oxygen species

Interventions

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Chemiluminescence Analyzer

measure reactive oxygen species

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Age \> 18 y/o
* Admitted to surgical ICU

Exclusion Criteria

* Patients with brain death
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Taiwan University Hospital

OTHER

Sponsor Role lead

Responsible Party

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National Taiwan University Hospital

Principal Investigators

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Yu-Chang Yeh

Role: PRINCIPAL_INVESTIGATOR

National Taiwan University Hospital

Locations

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National Taiwan University Hospital

Taipei, , Taiwan

Site Status RECRUITING

Countries

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Taiwan

Central Contacts

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Yu-Chang Yeh, MD

Role: CONTACT

[email protected]
886-9-68661829

Facility Contacts

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Yu-Chang Yeh, MD

Role: primary

[email protected]
886-9-68661829

Other Identifiers

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9561709132

Identifier Type: -

Identifier Source: org_study_id

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