Adrenal Exhaustion Syndrome in Critically Ill Patients Without Improvement

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

80 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-02-29

Study Completion Date

2008-05-31

Brief Summary

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We study the relationship between patient outcomes and sequential changes of serum cortisol level.

Detailed Description

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Elevated corticosteroid level to meet physiologic needs during acute illness is a protective response for stress. This homeostasis is maintained by the hypothalamic-pituitary-adrenal (HPA) axis. However, inadequate response as corticosteroid insufficiency in critically ill patients is reported with increasing frequency, especially in severe sepsis and septic shock. Thus, corticosteroids could be beneficial for septic shock or severe acute illness.

Once considered as normal adrenal function, adrenal insufficiency may developed later with chronic critical illness as adrenal exhaustion syndrome. It is easily overlooked and is possible due to the chronic secretion of systemic cytokines or other HPA axis-suppressive substances. There is still no consensus how often adrenal function testing should be repeated, although a re-evaluation should be considered if clinical symptoms and signs suggest adrenal insufficiency or deteriorating clinical condition.

Conditions

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Survival

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* age over 18
* ICU admission
* had two cortisol data

Exclusion Criteria

* first cortisol data abnormal
* cortisol data not checked in ICU

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Responsible Party

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National Taiwan University Hospital

Principal Investigators

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Chao-Chi Ho, MD

Role: STUDY_DIRECTOR

1. Department of Internal Medicine, National Taiwan University Hospital

Locations

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Chao-Chi Ho

Taipei, , Taiwan

Site Status

Countries

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Taiwan

Other Identifiers

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200802022R

Identifier Type: -

Identifier Source: org_study_id