Exhaled Nitric Oxide : Biomarker of Acute Respiratory Distress Syndrome

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

20 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-02-15

Study Completion Date

2025-01-05

Brief Summary

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The aim of the study is to see if endogenous exhaled Nitric Oxyde (eNO) concentrations measured are significantly higher in ARDS patients admitted in ICU ; compared to control subjects in good health with no lung disease or global inflammation, operated under general anesthesia (i.e. intubated and ventilated) for thyroid or parathyroid.

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Detailed Description

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The measurement of endogenous exhaled NO is monitored using a laser spectrometer machine connected to the expiratory circuit of the respirator. The measure is non-invasive and made by sampling expiratory gaz like for capnography.

In control subjects, the measurement period corresponds to the first ten minutes after induction of anesthesia (with intubation) before surgical incision.

In ARDS patients in intensive care, the measurement of eNO is made in the first twenty-four hours after intubation and ventilation of the patient with mechanical respirator.

The primary endpoint is a significantly higher eNO concentration in patients suffering from Acute Respiratory Distress Syndrome (ARDS).

Secondary endpoints will assess correlations between eNO concentrations and usual ARDS severity criteria: PaO2/FiO2; ventilator-free days; length of stay in intensive care and all-cause hospital mortality at 30 days.

Conditions

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ARDS, Human Nitric Oxyde

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Study Groups

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ARDS patients

ARDS patients admitted in ICU ;intubated and mechanically ventilated for less than 24 hours

Non invasive measure of endogenous exhaled Nitric Oxyde in exhaled gaz, by a laser spectrometer

Intervention Type OTHER

A sample of exhaled gases is taken from the expiratory part of the respirator circuit (same way as a capnometry measurement). A laser spectrometer continuously and non-invasively monitors online the concentrations of endogenous NO exhaled by patients.

Control group

Healthy subjects without pulmonary nor inflammatory pathology, who underwent a benign surgical procedure (thyroid or parathyroid surgery) requiring general anesthesia with intubation and mechanical ventilation.

Non invasive measure of endogenous exhaled Nitric Oxyde in exhaled gaz, by a laser spectrometer

Intervention Type OTHER

A sample of exhaled gases is taken from the expiratory part of the respirator circuit (same way as a capnometry measurement). A laser spectrometer continuously and non-invasively monitors online the concentrations of endogenous NO exhaled by patients.

Interventions

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Non invasive measure of endogenous exhaled Nitric Oxyde in exhaled gaz, by a laser spectrometer

A sample of exhaled gases is taken from the expiratory part of the respirator circuit (same way as a capnometry measurement). A laser spectrometer continuously and non-invasively monitors online the concentrations of endogenous NO exhaled by patients.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* For ARDS patients :

* Patients with ARDS (according to the Berlin criteria) admitted in intensive care unit and intubated for less than 24 hours.
* For control patients :

* Patients with no major disease (classified 1 or 2 in the classification of the American Society of Anaesthesiology)
* Patients undergoing general anaesthesia for a thyroïd or parathyroïd surgery