Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
250 participants
OBSERVATIONAL
2022-05-25
2024-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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Healthy controls
Healthy volunteers without conditions altering serotonin content in blood.
No interventions assigned to this group
Sepsis group
Patients with sepsis or septic shock admitted to ICU and receiving mechanical ventilation.
No interventions assigned to this group
Cardiac arrest group
Patients with cardiac arrest and ROSC admitted to ICU and receiving mechanical ventilation.
No interventions assigned to this group
Multiple trauma group
Patients with severe multiple trauma admitted to ICU and receiving mechanical ventilation.
No interventions assigned to this group
ICU control group
Patients with isolated neurological disease admitted to ICU and receiving mechanical ventilation.
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Age over 18 years
* Written consent from the patient or preliminary consent from the next of kin.
* Receiving mechanical ventilator treatment upon inclusion.
* Arterial and central venous cannulas present.
* Age over 18 years and signed written consent.
* Conformed to diet and activity restrictions.
* Status epilepticus, encephalitis, stroke, or other localized neurological disease.
* Age over 18 years
* Written consent from the patient or preliminary consent from the next of kin.
* Receiving mechanical ventilator treatment upon inclusion.
* Arterial and central venous cannulas present.
Exclusion Criteria
* Serotonergic carcinoid syndrome, short bowel or other considerable comorbidity altering serotonin content in blood.
* Intoxication prior to ICU admission.
HEALTHY CONTROLS
* Any acute illness or injury
* Ongoing autoimmune, malignant, infectious, or other inflammatory disease.
* Severe psychiatric disease or drug abuse.
* Use of any medication except oral contraceptives last two weeks.
* Withdrawal of consent.
ICU CONTROLS
* Withdrawal of consent
* Clinical signs of infection with focal symptoms or temperature over 38,0°C.
* Biochemical signs of infection or inflammation with leukocytes \> 11 x 10\^9/l, CRP \> 15 mg/l, or PCT \> 0,10 μg/l.
* Respiratory failure with PaO2/FiO2 ratio \< 40 kPa.
* Circulatory failure with MAP \< 60 or need for pressor treatment prior to sedation.
* Thrombocytopenia or thrombocytosis with platelets \< 100 or \> 400 x 10\^9/l.
* Serotonergic carcinoid syndrome, short bowel or other considerable comorbidity altering serotonin content in blood.
* Extracranial autoimmune or malignant disease.
* Severe psychiatric disease or drug abuse.
* Intoxication or physical trauma prior to ICU admission.
18 Years
ALL
Yes
Sponsors
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Oslo University Hospital
OTHER
Responsible Party
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Morten Rostrup
Senior physician and clinical professor, Department of Acute Medicine
Principal Investigators
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Morten Rostrup, MD PhD
Role: PRINCIPAL_INVESTIGATOR
Oslo University Hospital, University of Oslo
Locations
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Oslo University Hospital Ullevål
Oslo, , Norway
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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REK366749
Identifier Type: -
Identifier Source: org_study_id
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