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Analysis of Risk Factors and Prognostic Predictive Value in Sepsis Patients With Nutritional Risk

NCT ID: NCT07278167

Last Updated: 2025-12-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

400 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-03-01

Study Completion Date

2025-07-01

Brief Summary

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Sepsis is a common critical illness in intensive care units, characterized by systemic inflammatory response, immune dysfunction, microcirculatory issues, and multi-organ failure. These factors lead to high mortality rates and poor prognoses for patients. Nutritional risk is a significant complication in patients with sepsis, with a prevalence of 38% - 78. Sepsis-induced hypermetabolism and hypercatabolism result in increased energy expenditure and accelerated protein breakdown in affected patients, which subsequently exacerbates the risk of malnutrition. Malnutrition weakens immune function, reduces resistance to infections, and impairs immune regulation in sepsis patients. It worsens organ dysfunction, prolongs ICU hospitalization, and increases morbidity and mortality rates. Early identification and intervention for potential risk factors in patients with sepsis, particularly those with nutritional risk, is crucial for enhancing their prognosis. There is a notable lack of sensitive indicators for assessing the prognosis of sepsis patients at nutritional risk. Recent studies have begun exploring physical assessment measures in ICU settings as accessible and noninvasive tools for evaluation. This study aims to investigate the predictive value of nutritional laboratory indicators and physical measurements regarding the 28-day outcomes of ICU patients with sepsis and nutritional risk, providing a foundation for early clinical intervention.

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Detailed Description

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Conditions

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Sepsis Nutritional Risk

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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survivors/non-survivors

Retrospective data analysis, no intervention

Intervention Type OTHER

Retrospective data analysis, no intervention

Interventions

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Retrospective data analysis, no intervention

Retrospective data analysis, no intervention

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1. Met the diagnostic criteria for sepsis 3.0
2. Met the diagnostic criteria for nutritional risk (NRS-2002 score ≥ 3)
3. ICU stay≥2 days
4. Age ≥ 18

Exclusion Criteria

1. Edema
2. Tumor patients
3. Pregnancy
4. Lack of complete laboratory results
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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The Affiliated Hospital of Inner Mongolia Medical University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Jing Lin

Hohhot, , China

Site Status

Countries

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China

Other Identifiers

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AHInnerMongolia-NT

Identifier Type: -

Identifier Source: org_study_id

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