Sepsis in ICU:Causes and Outcomes in Diabetics and Non Diabetics

NCT ID: NCT05914480

Last Updated: 2023-06-26

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 85 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2023-07-31
• Study Completion Date: 2024-08-31

Brief Summary

Identify prevalence of sepsis in ICU of Assiut university hospital 2.Clarify different causes of sepsis in patients admitted to ICU . 3.Compare causes and outcomes of sepsis between diabetics versus non diabetics .

4.Screening for the co1.mmonest organism causing sepsis in critically ill patients .

Detailed Description

Sepsis, is defined as an infection with organ dysfunction, There is wide variation in sepsis rates, causative microorganisms, and outcome in ICU patients around the world.

Many conservative estimates considered sepsis as a leading cause of mortality and critical illness worldwide .

sepsis epidemiology studies worldwide revealed a highly variable incidence of 13-300 per 100,000 inhabitants per year for severe sepsis and 11 per 100,000 inhabitants per year for septic shock .

Factors such as advancing age, immunosuppression and multidrug-resistant infection play a role in increasing incidence of sepsis during recent decades .

Patients who survive sepsis often have long-term physical, psychological, and cognitive disabilities with significant health and social implications.

Patients with diabetes mellitus have an increased risk of developing infections and sepsis and they constitute 20.1-22.7% of all sepsis patients.

The prevalence of diabetes mellitus in ICU patients is as high as 30%, And such patients are at increased risk of experiencing in-hospital Complications, compared to patients without diabetes.

Infective complications may be reduced with lower blood glucose concentrations Moreover, in critically ill patients without diabetes, Hyperglycemia is associated with increased mortality, risk of infection, Kidney injury and cardiovascular complications.

Moreover, diabetes is a major risk factor for both Acute Kidney Injury and sepsis.

Sepsis also is a major cause of Acute Kidney Injury, which develops in one-fourth of all patients with sepsis and half of patients with bacteraemia or shock .

Sepsis-related AKI is associated with high mortality rates of up to 70%.

Conditions

Sepsis

Study Design

• Observational Model Type: CASE_ONLY
• Study Time Perspective: CROSS_SECTIONAL

Interventions

PCR for legionella ,blood ,urine cultures and from catheters or source of infection

Investigations to detect cause of sepsis as blood cultures ,urine cultures and from catheters .also PCR for legionella will be done

Intervention Type: OTHER

Eligibility Criteria

Exclusion Criteria

• previous history of pulmonary problem Previous history of cardiac disease Previous history of autoimmune disease

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Assiut University

OTHER

Sponsor Role: lead

Responsible Party

Mai Ahmed fathi mansour

Specialist

Responsibility Role: PRINCIPAL_INVESTIGATOR

Central Contacts

Mai Ahmed fathi, Specialist

Role: CONTACT

doc.maiahmad89@gmail.com

01009490399

Hala khalafalla el sherif, Professor

Role: CONTACT

dr_hala_elshereef@yahoo.com

01120110000

Other Identifiers

Sepsis pts investigate causes

Identifier Type: -

Identifier Source: org_study_id