Observation and Interactions Between Cardio-respiratory and Motor Transitions at the Limits of Moderate Exercise.

NCT ID: NCT06132724

Last Updated: 2025-04-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

20 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-12-05

Study Completion Date

2024-06-11

Brief Summary

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The goal of this observational study is to learn about physiological transitions around the limit of moderate exercise intensity on cardiac, respiratory and motor modalities, in healthy population.

The main questions it aims to answer is:

* is it possible to define criteria on cardiac, respiratory and motor modalities to identify transitions?
* are those transitions visible on embedded and non-intrusive monitoring equipment?
* are those identified transitions somehow connected to first ventilatory threshold (VT1)?

Participants will do a sub-maximal effort test on cycloergometer calibrated to make them cross their first ventilatory threshold.

Detailed Description

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Cycling is a commonly prescribed activity when it comes to physical activities for rehabilitation. Because it is soft and progressive effort, cycling suits well for patients with chronic conditions (diabete, cancer, fibromyalgia, ...) For safety and effectiveness of the activity, it is necessary to prescribe activity at a regular and moderate intensity. This can be achieved by personalizing intensities to match specifically the patient health condition in order to build an efficient and progressive rehabilitation program.

Physical activity prescription rely on four pillars: frequency, duration, volume and intensity. While first three pillars are quite easy to regulate,effort intensity is harder to handle on training planning. It is harder to measure, and defining personalized guideline for practice is more complex.

It is known that first ventilatory threshold (VT1) is a individualized marker representing the higher limit of moderate intensity effort zone. It makes it an interesting tool for the prescription of intensity for retraining purposes: it guaranties a safe practice, intense enough to make beneficial physiological adaptations for the patient.

In this retraining context and with this study, we aim to identify markers of this transition on cardiac, respiratory and motor modalities, with embedded and non intrusive equipment, during a sub-maximal effort test in laboratory.

Conditions

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Healthy

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Healthy Volunteers

Subjects who will agree to participate to the study will be healthy subject with no particular antecedents.

Subjects will be enroled for two sessions with a 20 min monitoring phase in each session, to coect physiological data with non invasive sensors.

Signal acquisition

Intervention Type OTHER

Synchronized signals from cardiac, respiratory and movements non invasive measurements.

One acquisition is 20 minutes long, and each subject participate to two sessions, separated by 1 to 15 days.

Interventions

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Signal acquisition

Synchronized signals from cardiac, respiratory and movements non invasive measurements.

One acquisition is 20 minutes long, and each subject participate to two sessions, separated by 1 to 15 days.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Capability to cycle during 20min
* No contraindication to cycling at a moderate pace
* No acute pathology (less than 2 years old)
* No cardiac or respiratory chronic pathology
* No locomotive problem on the spine or the lower limbs
* No recent injuries (less than 2 months)
* Stature compatible with the use of the plethysmography t-shirt

Exclusion Criteria

* Pregnant (urine strip test) or breastfeeding women
* Persons referred to in articles L1121-5 to L1121-8 of the CSP (protected persons) person deprived of liberty by judicial or administrative decision, person subject to a legal protection measure
* Subject being excluded from another study
* Subject who reached the ceiling of 4500 euros due to their participation in other studies involving human in the past 12 months
Minimum Eligible Age

18 Years

Maximum Eligible Age

64 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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TIMC-IMAG

OTHER

Sponsor Role collaborator

University Grenoble Alps

OTHER

Sponsor Role collaborator

University Hospital, Grenoble

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Plateforme PRETA P3I

Grenoble, , France

Site Status

Countries

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France

References

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Blair SN. Physical inactivity: the biggest public health problem of the 21st century. Br J Sports Med. 2009 Jan;43(1):1-2. No abstract available.

Reference Type BACKGROUND
PMID: 19136507 (View on PubMed)

Pisot R. Physical Inactivity - the Human Health's Greatest Enemy. Zdr Varst. 2021 Dec 27;61(1):1-5. doi: 10.2478/sjph-2022-0002. eCollection 2022 Mar.

Reference Type BACKGROUND
PMID: 35111260 (View on PubMed)

Meyler S, Bottoms L, Muniz-Pumares D. Biological and methodological factors affecting V̇O2max response variability to endurance training and the influence of exercise intensity prescription. Exp Physiol. 2021 Jul;106(7):1410-1424. doi: 10.1113/EP089565. Epub 2021 Jun 8.

Reference Type BACKGROUND
PMID: 34036650 (View on PubMed)

Succi PJ, Dinyer TK, Byrd MT, Bergstrom HC. Comparisons of the Metabolic Intensities at Heart Rate, Gas Exchange, and Ventilatory Thresholds. Int J Exerc Sci. 2020 May 1;13(2):455-469. doi: 10.70252/IBRC8606. eCollection 2020.

Reference Type BACKGROUND
PMID: 32509109 (View on PubMed)

Pouliquen C, Nicolas G, Bideau B, Garo G, Megret A, Delamarche P, Bideau N. Spatiotemporal analysis of 3D kinematic asymmetry in professional cycling during an incremental test to exhaustion. J Sports Sci. 2018 Oct;36(19):2155-2163. doi: 10.1080/02640414.2018.1432066. Epub 2018 Jan 30.

Reference Type BACKGROUND
PMID: 29381424 (View on PubMed)

Jamnick NA, Pettitt RW, Granata C, Pyne DB, Bishop DJ. An Examination and Critique of Current Methods to Determine Exercise Intensity. Sports Med. 2020 Oct;50(10):1729-1756. doi: 10.1007/s40279-020-01322-8.

Reference Type BACKGROUND
PMID: 32729096 (View on PubMed)

Other Identifiers

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38RC23.0263

Identifier Type: -

Identifier Source: org_study_id

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